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Comparison of 6th and 7th AJCC TNM Staging Classification for Carcinoma of the Stomach in China

  • Gastrointestinal Oncology
  • Published:
Annals of Surgical Oncology Aims and scope Submit manuscript

Abstract

Background

The 7th edition of American Joint Committee on Cancer tumor-node-metastasis (AJCC TNM) staging system was put into use recently. The study aimed to evaluate its predictive ability on survival and compare the difference between the 6th and 7th editions of AJCC TNM system in gastric carcinoma.

Materials and Methods

A total of 1000 gastric carcinoma patients receiving treatment in our center were selected for the analysis. Patients were staged using both the 6th and 7th editions AJCC TNM staging system. Survival analysis was performed with a Cox regression model.

Results

Of previous stage IV patients, 39.9% (112 of 281) migrated to a lower tier in the 7th edition. By setting the cutoff of positive lymph nodes as 0, 2, 6, and 15, the 7th edition strengthens the role of positive lymph nodes. Multivariable regression analysis showed that both 6th and 7th TNM stage systems were independent factors for overall survival. For lymph nodes negative patients, the 5-year overall survival for patients with fewer than 15 resected lymph nodes was significantly lower than those with more than 15.

Conclusions

AJCC 7th is not superior to AJCC 6th in predicting the 5-year overall survival rates of gastric adenocarcinoma patients. The definition of stage IV and the selection of cutoffs for MLNC in the AJCC 7th system is much more reasonable compared with the AJCC 6th system.

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Acknowledgment

This work was supported by National Natural Science Foundation of China grant 30672408, Guangzhou Bureau of Science and Technology grant 2006Z3-E0041, and Sun Yat-sen University 985 Program Initiation Fund (China). We gratefully thank the staff members in the Department of Medical Oncology and GI Surgery Oncology at Sun Yat-sen University Cancer Center for their suggestion and assistance.

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Authors and Affiliations

  1. State Key Laboratory of Oncology in South China, Guangzhou, China

    Miao-zhen Qiu MD, Zhi-qiang Wang MD, Dong-sheng Zhang MD, PhD, Qing Liu MD, PhD, Hui-yan Luo MD, Zhi-wei Zhou MD, PhD, Yu-hong Li MD, PhD, Wen-qi Jiang MD, PhD & Rui-hua Xu MD, PhD

  2. Department of Medical Oncology, Sun Yat-Sen University Cancer Center, Guangzhou, China

    Miao-zhen Qiu MD, Zhi-qiang Wang MD, Dong-sheng Zhang MD, PhD, Hui-yan Luo MD, Yu-hong Li MD, PhD, Wen-qi Jiang MD, PhD & Rui-hua Xu MD, PhD

  3. Department of GI Surgery, Sun Yat-Sen University Cancer Center, Guangzhou, China

    Zhi-wei Zhou MD, PhD

  4. Department of Epidemiology, Sun Yat-Sen University Cancer Center, Guangzhou, China

    Qing Liu MD, PhD

Authors
  1. Miao-zhen Qiu MD
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  2. Zhi-qiang Wang MD
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  3. Dong-sheng Zhang MD, PhD
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  4. Qing Liu MD, PhD
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  5. Hui-yan Luo MD
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  6. Zhi-wei Zhou MD, PhD
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  7. Yu-hong Li MD, PhD
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  8. Wen-qi Jiang MD, PhD
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  9. Rui-hua Xu MD, PhD
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Corresponding author

Correspondence to Rui-hua Xu MD, PhD.

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Qiu, Mz., Wang, Zq., Zhang, Ds. et al. Comparison of 6th and 7th AJCC TNM Staging Classification for Carcinoma of the Stomach in China. Ann Surg Oncol 18, 1869–1876 (2011). https://doi.org/10.1245/s10434-010-1542-x

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  • DOI: https://doi.org/10.1245/s10434-010-1542-x

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