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Potential Applications and Additive Manufacturing Technology-Based Considerations of Mesoporous Silica: A Review

  • Review Article
  • Novel Advances in 3-D Printing Technology in Drug Delivery
  • Published:
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Abstract

Nanoporous materials are categorized as microporous (pore sizes 0.2–2 nm), mesoporous (pore sizes 2–50 nm), and macroporous (pore sizes 50–1000 nm). Mesoporous silica (MS) has gained a significant interest due to its notable characteristics, including organized pore networks, specific surface areas, and the ability to be integrated in a variety of morphologies. Recently, MS has been widely accepted by range of manufacturer and as drug carrier. Moreover, silica nanoparticles containing mesopores, also known as mesoporous silica nanoparticles (MSNs), have attracted widespread attention in additive manufacturing (AM). AM commonly known as three-dimensional printing is the formalized rapid prototyping (RP) technology. AM techniques, in comparison to conventional methods, aid in reducing the necessity for tooling and allow versatility in product and design customization. There are generally several types of AM processes reported including VAT polymerization (VP), powder bed fusion (PBF), sheet lamination (SL), material extrusion (ME), binder jetting (BJ), direct energy deposition (DED), and material jetting (MJ). Furthermore, AM techniques are utilized in fabrication of various classified fields such as architectural modeling, fuel cell manufacturing, lightweight machines, medical, and fabrication of drug delivery systems. The review concisely elaborates on applications of mesoporous silica as versatile material in fabrication of various AM-based pharmaceutical products with an elaboration on various AM techniques to reduce the knowledge gap.

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Data Availability

Data can be made available on request to corresponding authors.

Abbreviations

MSNs:

Mesoporous silica nanoparticles

AM:

Additive manufacturing

RP:

Rapid prototyping

VP:

VAT polymerization

PBF:

Powder bed fusion

SL:

Sheet lamination

ME:

Material extrusion

BJ:

Binder jetting

DED:

Direct energy deposition

MJ:

Material jetting

3D:

Three-dimensional

4D:

Four-dimensional

CAD:

Computer-aided design

CO2 :

Carbon dioxide

FDM:

Fused deposition modeling

(8):

Stereolithography

SLS:

Selective laser sintering

PBF:

Powder bed fusion

DLP:

Digital light processing

MS:

Mesoporous silica

IUPAC:

International Union of Pure and Applied Chemistry

DOX:

Doxorubicin

(69):

Polyethylene glycol

CLIP:

Continuous liquid interface production

TPP:

Two-photon polymerization

EBM:

Electron beam melting

(183):

Laminated object manufacturing

(96):

Ultrasonic additive manufacturing

HME:

Hot melt extrusion

FDM:

Fused deposition modeling

LENS:

Laser-engineered net shaping

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Funding

This work was partially supported by CMU Proactive Researcher Scheme (2023), Chiang Mai University “Contract No. 933/2566”.

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Authors and Affiliations

  1. Sigma Institute of Pharmacy, Vadodara, Gujarat, 390019, India

    Jigar Vyas & Isha Shah

  2. Department of Pharmaceutical Sciences, Faculty of Pharmacy, Chiang Mai University, Chiang Mai, 50200, Thailand

    Sudarshan Singh

  3. Office of Research Administration, Chiang mai University, Chiang Mai, 50200, Thailand

    Sudarshan Singh & Bhupendra G. Prajapati

  4. Shree S. K. Patel College of Pharmaceutical Education and Research, Ganpat University, Kherva, 384012, India

    Bhupendra G. Prajapati

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Contributions

Conceptualization, SS and BGP; methodology, JV and IS; software, JV and IS; validation, SS and BGP; formal analysis, JJ; investigation, JV and IS; resources, SS; data curation, SS; writing original draft preparation, JV and IS; writing review and editing, SS; visualization, BGP; supervision, BGP and SS; and project administration, SS and BGP. All authors have read and agreed to the published version of the manuscript.

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Vyas, J., Singh, S., Shah, I. et al. Potential Applications and Additive Manufacturing Technology-Based Considerations of Mesoporous Silica: A Review. AAPS PharmSciTech 25, 6 (2024). https://doi.org/10.1208/s12249-023-02720-7

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