Abstract
The clinical presentation of severe infection with generalized inflammation is similar, if not identical, to systemic inflammation induced by sterile tissue injury. Novel models and unbiased technologies are urgently needed for biomarker identification and disease profiling in sepsis. Here we briefly review the article of Kamisoglu and colleagues in this issue of Critical Care on comparing metabolomics data from different studies to assess whether responses elicited by endotoxin recapitulate, at least in part, those seen in clinical sepsis.
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Abbreviations
- CAPSOD:
-
Community acquired pneumonia and sepsis outcome and diagnostics
- GC:
-
Gas chromatography
- LC:
-
Liquid chromatography
- MS:
-
Mass spectrometry
- NMR:
-
Nuclear magnetic resonance
- SIRS:
-
Systemic inflammatory response syndrome
- TLR:
-
Toll like receptor
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See related research by Kamisoglu et al., http://ccforum.com/content/19/1/71
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dos Santos, C.C. Shedding metabo‘light’ on the search for sepsis biomarkers. Crit Care 19, 277 (2015). https://doi.org/10.1186/s13054-015-0969-7
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DOI: https://doi.org/10.1186/s13054-015-0969-7