Introduction

Yemen has been suffering from a devastating civil war since 2015, which has resulted in more than 230,000 deaths, 4 million displacements, and 24 million people needing humanitarian aid [1]. The conflict has also crippled the health system and the provision of medical care, especially for trauma victims [2].

War-related trauma often leads to orthopedic injuries, which can impair health, well-being, and livelihoods [3]. However, their scope, treatment, and outcomes in Yemen are poorly understood. This is the first study to address this gap. We analyzed data from 3685 patients with war-related orthopedic injuries treated at three Sana’a University teaching hospitals from January 2015 to December 2020. We aimed to describe their characteristics, causes, complications, interventions, and outcomes. We hypothesized that these injuries are complex and hard to manage, and linked to high rates of infection, amputation, and mortality.

Orthopedic injuries are among the most common and severe consequences of war-related trauma [4]. They can affect various parts of the musculoskeletal system, such as bones, joints, muscles, tendons, and ligaments. They can range from simple fractures and soft tissue injuries to complex limb-threatening wounds and polytrauma. They can also result in chronic pain, disability, deformity, and psychological distress [5].

The management of orthopedic injuries in war settings poses many challenges for health care providers. These include limited resources, inadequate infrastructure, lack of trained personnel, frequent infections, delayed presentations, and poor follow-up [6]. Moreover, the ongoing violence and insecurity can hamper the access to health facilities and the delivery of humanitarian assistance [7].

In Yemen, the situation is particularly dire. The country has been facing one of the worst humanitarian crises in the world due to the prolonged conflict that has devastated its economy, infrastructure, and health system [1]. According to Doctors Without Borders/Médecins Sans Frontières (MSF), more than half of the health facilities in Yemen are either non-functional or partially functional, and many people have no access to basic health care services [7]. Furthermore, the country is facing outbreaks of cholera, diphtheria, malaria, and COVID-19, which add to the burden of disease and mortality [7].

Despite these challenges, no previous studies have systematically investigated the patterns and characteristics of orthopedic injuries in Yemeni patients affected by war-related trauma. This highlights a critical gap in our understanding of the impact of conflict on the musculoskeletal system, and the urgent need for research in this area.

This study aims to fill this gap by using a large dataset from three Sana’a University teaching hospitals that treated patients with war-related orthopedic injuries from January 2015 to December 2020. These hospitals are Al-Thawra Hospital, Al-Jumhuri Hospital, and Al-Kuwait Hospital, which are among the main referral centers for trauma care in Yemen. We used descriptive and inferential statistics to analyze the data and answer the following research questions:

  • What are the demographic characteristics of patients with war-related orthopedic injuries?

  • What are the types and causes of war-related orthopedic injuries?

  • What are the surgical interventions performed for war-related orthopedic injuries?

  • What are the complications and outcomes of war-related orthopedic injuries?

  • How do these variables differ by age group,gender and injury location?

By answering these questions, we hope to provide a comprehensive overview of the patterns and characteristics of orthopedic injuries in Yemeni patients affected by war-related trauma. We also hope to identify the gaps and challenges in the management and outcome of these injuries, and to suggest recommendations for improving the quality of care and reducing the morbidity and mortality associated with these injuries.

Methods

This was a retrospective study based on medical records and trauma registries of patients with war-related orthopedic injuries treated at three Sana’a University teaching hospitals (Al-Thawra, Al-Jhumhori, Al-Kuwait) in Yemen from January 2015 to December 2020. These hospitals are the main referral centers for trauma care in the capital city and receive patients from all over the country. The study was conducted in the context of the ongoing civil war in Yemen, which has been exacerbated by the military intervention of a Saudi-led coalition since March 2015. The study was approved by the institutional review board of Sana’a University and informed consent was waived due to the retrospective nature of the study.

We included all patients who were admitted to the hospitals with war-related orthopedic injuries during the study period. We excluded patients who had non-war-related orthopedic injuries, such as falls or sports injuries, or who had missing or incomplete data. We collected data on demographics (age, sex, occupation), injury mechanisms (gunshot wounds, blast injuries, landmine explosions, motor vehicle accidents), injury types and locations (fractures, soft-tissue injuries, amputations), surgical procedures (debridement and irrigation, external fixation, internal fixation), complications (infection, nonunion, malunion), and mortality (in-hospital death). We also collected data on functional outcomes using the Musculoskeletal Function Assessment (MFA) questionnaire [8], which is a validated instrument that measures physical impairment and disability in patients with musculoskeletal disorders. The MFA consists of 100 items that cover eight domains: daily activities, emotional status, arm function, hand function, mobility function, walking function, work function, and social function. The MFA score ranges from 0 to 100, with higher scores indicating worse function.

We analyzed the data using descriptive and inferential statistics. We used frequencies and percentages for categorical variables and means and standard deviations for continuous variables. We used chi-square tests for comparing categorical variables and t-tests or analysis of variance for comparing continuous variables. We used logistic regression to identify the factors associated with increased mortality among patients with war-related orthopedic injuries. We considered a p-value of less than 0.05 as statistically significant. We used SPSS version 25 for data analysis (Table 1).

Table 1 Logistic regression analysis of factors associated with mortality among patients with war-related orthopedic injuries
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Results

We analyzed the data of 3930 patients with war-related orthopedic injuries who were admitted to three trauma centers in Sana’a city from January 2015 to December 2020. The patients were predominantly young males (85%) and civilians (72%), with a mean age of 28 years (range 6–75 years). Table 2 summarizes the demographic characteristics of the patients by sex, occupation, and year of injury. The most common mechanisms of injury were gunshot wounds (42%), blast injuries (35%), and landmine explosions (12%), which resulted in complex and severe injuries involving multiple body regions. The lower extremities (56%), upper extremities (25%), and pelvis (9%) were the most frequently injured body regions. Table 3 shows the frequency and percentage of injuries by body region and mechanism. The majority of injuries involved open fractures (76%) with associated soft-tissue injuries in 88% of cases. The most prevalent soft-tissue injuries were vascular injuries (12%), nerve injuries (10%), and abdominal injuries (8%). Table 4 presents the frequency and percentage of soft-tissue injuries by body region and type. The patients underwent various surgical procedures and received different types of implants. The most frequent surgical procedures were external fixation (36%), debridement and irrigation (28%), and internal fixation (16%). The most commonly used implants were Kirschner wires (28%), intramedullary nails (22%), and plates and screws (18%). Table 5 displays the frequency and percentage of surgical procedures and implants by body region. The overall complication rate was 29%, with infection being the most prevalent complication (18%). Other complications included nonunion (6%), malunion (4%), and amputation (3%). Table 6 illustrates the frequency and percentage of complications by body region and type. The overall mortality rate was 7%, with sepsis being the main cause of death (34%).Other causes of death included multiple organ failure (26%), hemorrhage (18%), and pulmonary embolism (12%). Table 7 depicts the frequency and percentage of causes of death by mechanism of injury. The mean length of hospital stay was 15 days, and the mean length of follow-up was 12 months. The functional outcomes were poor, as indicated by the high mean MFA score of 38. Table 8 demonstrates the mean and standard deviation of functional outcomes by body region and mechanism of injury.

Table 2 Distribution of patients by sex, occupation, and year of injury
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Table 3 Distribution of injuries by body region and mechanism
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Table 4 Distribution of soft-tissue injuries by body region and type
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Table 5 Distribution of surgical procedures and implants by body region
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Table 6 Distribution of complications by body region and type
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Table 7 Distribution of causes of death by mechanism of injury
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Table 8 Distribution of functional outcomes by body region and mechanism of injury
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We performed a hierarchical logistic regression analysis to identify the factors associated with mortality as the outcome variable among patients with war-related orthopedic injuries. We adjusted for potential confounders such as sex, occupation, and injury location. We found that older age (> 40 years), blast injuries, spine injuries, vascular injuries, and infection were significant predictors of mortality.

Discussion

This study aimed to describe the epidemiology, characteristics, and outcomes of war-related orthopedic injuries in Yemen, a country that has been suffering from a protracted civil war and humanitarian crisis since 2015. To our knowledge, this is the first study to report on the war-related orthopedic injuries in Yemen using a large sample of patients from three major trauma centers in the capital city.

Our findings show that most of the patients were young males and civilians, which is consistent with previous studies on war-related injuries in other countries [9,10,11]. The main mechanisms of injury were gunshot wounds, blast injuries, and landmine explosions, which resulted in complex and severe injuries involving multiple body regions, especially the lower extremities. These injuries often required multiple surgical procedures and implants, and were associated with high rates of complications and mortality. The most common complications were infection, nonunion, malunion, and amputation. The most common cause of death was sepsis. The functional outcomes were poor, as indicated by the high mean MFA score.

Our study has several implications for the management of war-related orthopedic injuries. First, it highlights the need for timely and adequate trauma care for the war-wounded patients, including prompt evacuation, resuscitation, wound debridement, fracture stabilization, antibiotic prophylaxis, and tetanus immunization [12]. Second, it underscores the importance of preventing and treating infection, which is a major challenge in war settings due to the nature of the wounds, the lack of sterile conditions, the scarcity of resources, and the emergence of multidrug-resistant organisms [13]. Third, it emphasizes the need for improving the surgical techniques and implant materials for the reconstruction of large segmental defects and soft-tissue defects [14]. Fourth, it stresses the need for providing comprehensive rehabilitation services and psychosocial support for the patients who suffer from permanent disability and reduced quality of life [15].

Our study also has some limitations that should be acknowledged. First, it was a retrospective study based on medical records and trauma registries, which may have some missing or inaccurate data. Second, it was conducted in three hospitals in Sana’a city, which may not represent the whole country or other regions with different patterns of injury or access to care. Third, it did not include long-term follow-up data on the patients’ outcomes or satisfaction. Fourth, it did not compare the outcomes of different surgical procedures or implants. Fifth, it did not adjust for potential confounders such as comorbidities or smoking status in the logistic regression analysis.

Despite these limitations, our study provides valuable information on the war-related orthopedic injuries in Yemen and their impact on the patients’ health and function. Our study also identifies some areas for future research, such as exploring the risk factors for infection and nonunion/malunion, evaluating the effectiveness and cost-effectiveness of different surgical procedures and implants, assessing the long-term outcomes and quality of life of the patients, and developing novel strategies to enhance bone and soft-tissue healing.

Conclusion

This paper presented a retrospective study of war-related orthopedic injuries in Yemen, a country that has been experiencing a devastating civil war and humanitarian crisis since 2015. The study described the epidemiology, characteristics, and outcomes of 3930 patients who were treated at three major trauma centers in Sana’a city from January 2015 to December 2020. The study found that most of the patients were young males and civilians who suffered from complex and severe injuries involving multiple body regions, especially the lower extremities. The study also found that the patients required multiple surgical procedures and implants, and had high rates of complications and mortality. The study identified infection, nonunion, malunion, and amputation as the most common complications, and sepsis as the main cause of death. The study also assessed the functional outcomes using the MFA questionnaire and found that the patients had poor function. The study performed a logistic regression analysis and found that older age, blast injuries, spine injuries, vascular injuries, and infection were significant predictors of mortality.

The study has several implications for the management of war-related orthopedic injuries

It highlights the need for timely and adequate trauma care for the war-wounded patients, including prompt evacuation, resuscitation, wound debridement, fracture stabilization, antibiotic prophylaxis, and tetanus immunization. It underscores the importance of preventing and treating infection, which is a major challenge in war settings due to the nature of the wounds, the lack of sterile conditions, the scarcity of resources, and the emergence of multidrug-resistant organisms. It emphasizes the need for improving the surgical techniques and implant materials for the reconstruction of large segmental defects and soft-tissue defects. It stresses the need for providing comprehensive rehabilitation services and psychosocial support for the patients who suffer from permanent disability and reduced quality of life.

The study also has some limitations that should be acknowledged. It was a retrospective study based on medical records and trauma registries, which may have some missing or inaccurate data. It was conducted in three hospitals in Sana’a city, which may not represent the whole country or other regions with different patterns of injury or access to care. It did not include long-term follow-up data on the patients’ outcomes or satisfaction. It did not compare the outcomes of different surgical procedures or implants. It did not adjust for potential confounders such as comorbidities or smoking status in the logistic regression analysis.

Despite these limitations, this paper provides valuable information on the war-related orthopedic injuries in Yemen and their impact on the patients’ health and function. This paper also identifies some areas for future research, such as exploring the risk factors for infection and nonunion/malunion, evaluating the effectiveness and cost-effectiveness of different surgical procedures and implants, assessing the long-term outcomes and quality of life of the patients, and developing novel strategies to enhance bone and soft-tissue healing.