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Antibiotics Prophylaxis for Operative Hysteroscopy: A Multicenter Randomized Controlled Clinical Study

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Abstract

Objective: To evaluate the incidence of infectious complications and effect of prophylactic antibiotic administration during operative hysteroscopic procedures. Methods: A multicentric randomized controlled trial was conducted between January 2012 and December 2013. Women (n = 180) affected by endometrial hyperplasia, myomas, or endometrial polyps undergoing operative hysteroscopy were randomized to receive cefazolin 2 g intravenously 30 minutes prior to the procedure (n = 91) and no treatment (n = 89). Results: No statistical difference in terms of postoperative fever (2.4% vs 2.3%, P = .99), endometritis (0% vs 0%), pain (6.0% vs 10.4%, P = .40), cervicitis-vaginitis (0% vs 0%), pelvic abscess (0% vs 0%), pelvic inflammatory disease (0% vs 0%), and bleeding (0% vs 0%) was noticed. No statistical difference in terms of side effects attributable to antibiotic prophylaxis such as allergy (0% vs 4.8%, P = .12), nausea (10.7% vs 17.4%, P = .27), vomiting (3.6% vs 4.6%, P = .99), diarrhea (4.8% vs 5.4%, P = .99), cephalea (9.5% vs 3.5%, P = .13), dizziness (4.8% vs 2.3%, P = .44), and meteorism (5.4% vs 3.4%, P = .99) was noticed. Conclusion: The results of the current study support the recommendation not to prescribe routine antibiotic prophylaxis prior to operative hysteroscopy.

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References

  1. ACOG practice bulletin No. 104: antibiotic prophylaxis for gynecologic procedures. Obstet Gynecol. 2009;113(5):1180–1189.

    Article  Google Scholar 

  2. Van Eyk N, van Schalkwyk J; Infectious Diseases Committee. Antibiotic prophylaxis in gynaecologic procedures. J Obstet Gynaecol Can. 2012;34(4):382–391.

    Article  Google Scholar 

  3. Morrill MY, Schimpf MO, Abed H, et al. Society of Gynecologic Surgeons Systematic Review Group. Antibiotic prophylaxis for selected gynecologic surgeries. Int J Gynaecol Obstet. 2013;120(1):10–15.

    CAS  PubMed  Google Scholar 

  4. Benedetti Panici P, Manci N, Bellati F, et al. CO2 laser therapy of the Bartholin’s gland cyst: surgical data and functional short- and long-term results. J Minim Invasive Gynecol. 2007;14(3):348–351.

    Article  Google Scholar 

  5. Thinkhamrop J, Laopaiboon M, Lumbiganon P. Prophylactic antibiotics for transcervical intrauterine procedures. Cochrane Database Syst Rev. 2013;(5):CD005637. doi:10.1002/14651858. CD005637.

    Google Scholar 

  6. Pocok SJ, Simon R. Sequential assignment with balancing for prognostic factors in the controlled clinical trial. Biometrics. 1975;31(3):103–215.

    Article  Google Scholar 

  7. Idsoe O, Guthe T, Willcox RR, de Weck AL. Nature and extent of penicillin side-reactions, with particular reference to fatalities from anaphylactic shock. Bull World Health Org. 1968;38(2):159–188.

    CAS  PubMed  Google Scholar 

  8. Lema VM, Majinge CR. Acute pelvic infection following hyster-osalpingography at the Kenyatta National Hospital, Nairobi. East Afr Med J. 1993;70(9):551–555.

    CAS  PubMed  Google Scholar 

  9. Agostini A, Cravello L, Shojai R, Ronda I, Roger V, Blanc B. Postoperative infection and surgical hysteroscopy. Fertil Steril. 2002;77(4):766–768.

    Article  Google Scholar 

  10. Bhattacharya S, Parkin DE, Reid TM, Abramovich DR, Mollison J, Kitchener HC. A prospective randomised study of the effects of prophylactic antibiotics on the incidence of bacteraemia following hysteroscopic surgery. Eur J Obstet Gynecol Reprod Biol. 1995;63(1):37–40.

    Article  CAS  Google Scholar 

  11. Kasius JC, Broekmans FJ, Fauser BC, Devroey P, Fatemi HM. Antibiotic prophylaxis for hysteroscopy evaluation of the uterine cavity. Fertil Steril. 2011;95(2):792–794.

    Article  CAS  Google Scholar 

  12. Nappi L, Di Spiezio, Sardo A, et al. A multicenter, double-blind, randomized, placebo-controlled study to assess whether antibiotic administration should be recommended during office operative hysteroscopy. Reprod Sci. 2013;20(7):755–761.

    Article  Google Scholar 

  13. Garry R, Shelley-Jones D, Mooney P, Phillips G. Six hundred endometrial laser ablations. Obstet Gynecol. 1995;85(1):24–29.

    Article  CAS  Google Scholar 

  14. McCausland VM, Fields GA, McCausland AM, Townsend DE. Tuboovarian abscesses after operative hysteroscopy. J Reprod Med. 1993;38(3):198–200.

    CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Gynecology, Obstetrics, and Urology, Sapienza University of Rome, Viale Del Policlinico, 00155, Rome, Italy

    Ludovico Muzii MD, Violante Di Donato MD, PhD, Terenzio Boni MD, Ludovica Imperiale MD, Caterina De Medici MD & Pierluigi Benedetti Panici MD

  2. Department of Obstetrics and Gynecology, Catholic University of the Sacred Heart, Rome, Italy

    Raffaele Gaglione MD & Riccardo Marana MD

  3. Arbor Vitae Center for Endoscopic Gynecology, Clinica Nuova Villa Claudia, Rome, Italy

    Ivan Mazzon MD

  4. Department of Obstetrics and Gynecology, University of Rome Campus Bio-Medico, Rome, Italy

    Alfonso Ruggiero MD

Authors
  1. Ludovico Muzii MD
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  2. Violante Di Donato MD, PhD
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  3. Terenzio Boni MD
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  4. Raffaele Gaglione MD
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  5. Riccardo Marana MD
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  6. Ivan Mazzon MD
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  7. Ludovica Imperiale MD
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  8. Caterina De Medici MD
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  9. Alfonso Ruggiero MD
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  10. Pierluigi Benedetti Panici MD
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Corresponding author

Correspondence to Violante Di Donato MD, PhD.

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Muzii, L., Donato, V.D., Boni, T. et al. Antibiotics Prophylaxis for Operative Hysteroscopy: A Multicenter Randomized Controlled Clinical Study. Reprod. Sci. 24, 534–538 (2017). https://doi.org/10.1177/1933719116660848

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