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Polymorphisms in Inflammatory Mediator Genes and Risk of Preeclampsia in Taiyuan, China

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Abstract

Excessive maternal inflammatory response is involved in the pathogenesis of preeclampsia. Few epidemiologic studies have investigated the associations between genetic variations in the inflammatory mediator genes and preeclampsia risk, and these studies have reached inconsistent results. We examined 31 single-nucleotide polymorphisms in IL-1A, IL-1B, IL-1R1, IL-2RA, IL-5RA, IL-6, IL-6R, TNFSF11, TNFRSF11A, IL-28RA, IRAK4, and KIT genes and the risk of preeclampsia and its clinical subtypes in a nested case-control study including 203 preeclampsia cases and 233 controls. We found that IL-1R1, IL-5RA, IL-6R, and TNFSF11 were associated with the risk of preeclampsia. Although the significant associations observed for preeclampsia overall were mainly seen for late-onset preeclampsia and severe preeclampsia, IL-6R (rs2229238) and TNFSF11 (rs9525643) polymorphisms were associated with the risk of early-onset preeclampsia. TNFSF11 (rs2200287 and rs2148072) polymorphisms were associated with risk of mild preeclampsia. Our study provided the first evidence that genetic variations in inflammatory mediator genes IL-1R1, IL-6R, TNFSF11, and IL-5RA were associated with preeclampsia risk, and the risk varied by preeclampsia subtypes.

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Authors and Affiliations

  1. Department of Epidemiology, Shanxi Medical University School of Public Health, 56 Xin-Jian South Road, Taiyuan, Shanxi, China

    Weiwei Wu MD, Yongliang Feng MD, PhD, Ping Zhang MD, Tingting Peng MD, Fang Wang MD, Bingjie Xie MD, Pengge Guo MD, Mei Li MD, Ying Wang MD, Suping Wang MD, PhD & Yawei Zhang MD, PhD

  2. Department of Obstetrics, the First Affiliated Hospital, Shanxi Medical University, Taiyuan, China

    Hailan Yang MD, PhD

  3. Department of Information, the First Affiliated Hospital, Shanxi Medical University, Taiyuan, China

    Shuzhen Li MD, PhD

  4. Center For Disease Control and Prevention, Taiyuan Railway Administration, Taiyuan, China

    Xin Wang MD

  5. Department of Environmental Health Sciences, Yale School of Public Health, 60 College Street, New Haven, CT, 06520, USA

    Nan Zhao MD & Yawei Zhang MD, PhD

Authors
  1. Weiwei Wu MD
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  2. Hailan Yang MD, PhD
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  3. Yongliang Feng MD, PhD
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  5. Shuzhen Li MD, PhD
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  6. Xin Wang MD
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  13. Nan Zhao MD
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  14. Suping Wang MD, PhD
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  15. Yawei Zhang MD, PhD
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Correspondence to Suping Wang MD, PhD or Yawei Zhang MD, PhD.

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Wu, W., Yang, H., Feng, Y. et al. Polymorphisms in Inflammatory Mediator Genes and Risk of Preeclampsia in Taiyuan, China. Reprod. Sci. 24, 539–547 (2017). https://doi.org/10.1177/1933719116660844

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  • DOI: https://doi.org/10.1177/1933719116660844

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