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The Presence of Human Chorionic Gonadotropin/Luteinizing Hormone Receptors in Pancreatic β-Cells

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Abstract

We investigated the possible presence of functional human chorionic gonadotropin (hCG)/luteinizing hormone (LH) receptors in β-cells of pancreas, using a combination of techniques on hCG/LH receptor knockout mice, immortalized rat insulinoma cells, and human pancreatic islets. The results showed the presence of receptors and their activation resulted in a dose-dependent increase in glucose-induced release of insulin. These findings place hCG and LH among the regulators of insulin release with potential implications for insulin-level changes during the periods of altered hCG and LH secretion.

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Authors and Affiliations

  1. Department of Environmental and Occupational Health, Robert Stempel College of Public Health and Social Work, Florida International University, FL, Miami, USA

    Jai Parkash PhD

  2. Keiser University, FL, Fort Myers, USA

    Jai Parkash PhD

  3. Department of Obstetrics and Gynecology, University of Louisville Medical Center, KY, Louisville, USA

    Zhenmin Lei MD, PhD

  4. Department of Cellular Biology and Pharmacology, Herbert Wertheim College of Medicine, Florida International University, 33199, FL, Miami, USA

    C. V. Rao PhD

Authors
  1. Jai Parkash PhD
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  2. Zhenmin Lei MD, PhD
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  3. C. V. Rao PhD
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Correspondence to C. V. Rao PhD.

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Parkash, J., Lei, Z. & Rao, C.V. The Presence of Human Chorionic Gonadotropin/Luteinizing Hormone Receptors in Pancreatic β-Cells. Reprod. Sci. 22, 1000–1007 (2015). https://doi.org/10.1177/1933719115570910

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