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Roles of Sphingosine-1-Phosphate in Reproduction

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Abstract

Sphingosine-1-phosphate (S1P) plays crucial roles in the regulation of cell growth, proliferation, differentiation, cell survival, migration, and angiogenesis. In the reproductive system, S1P protects mammalian germ cells from irradiation or chemotherapy-induced cell death in vivo and in vitro. Moreover, S1P could improve the survival rate of thawed ovary and transplanted ovary. Furthermore, S1P could improve the developmental potential of oocyte and preimplantation embryo. In conclusion, S1P plays important roles in reproduction.

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Authors and Affiliations

  1. Department of Obstetrics and Gynecology, Center for Reproductive Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, China

    Lei Guo PhD, Xianghong Ou MD & Hong Li MD

  2. State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, #1 Beichen West Road, Chaoyang District, 100101, Beijing, China

    Zhiming Han PhD

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  1. Lei Guo PhD
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Correspondence to Zhiming Han PhD.

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Guo, L., Ou, X., Li, H. et al. Roles of Sphingosine-1-Phosphate in Reproduction. Reprod. Sci. 21, 550–554 (2014). https://doi.org/10.1177/1933719113512534

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