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Intracortical synchronization pattern on the preclinical and clinical stages of absence epilepsy (analysis of wavelet bicoherence in WAG/Rij rats)

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Abstract

Here we examine the intracortical synchronization pattern in freely moving WAG/Rij rats (valid animal model of absence epilepsy). In all rats, electrocorticograms were recorded at the age 5 and 9 months (i.e., preclinical and clinical stages of absence epilepsy in epileptic subjects). To assess intracortical synchronization pattern, we measured wavelet bicoherence in unilateral (fronto-frontal) and bilateral (fronto-occipital) electrode pairs in five non-overlapping frequency bands (“1–4 Hz”; “5–9 Hz”; “9–12 Hz”; “12–14 Hz”; “14–20 Hz”) and two additional bands “0.5–1.5 Hz”; “10–14 Hz” bands. Bilateral fronto-frontal synchronization in epileptic subjects was lower than in non-epileptic ones only on the clinical stage of absence epilepsy. Unilateral fronto-occipital synchronization in epileptic rats was lower (“5–9 Hz” and “10–14 Hz”) than in non-epileptic ones only on preclinical stage. This finding may be interpreted as a marker of thalamo-cortical impairment associated with epileptogenic processes underlying long-term progression of absence epilepsy. We construct plots of synchronization patterns or diagnostic maps, which can be used for early diagnosis of absence epilepsy in predisposed subjects.

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Data Availability Statement

The datasets generated during and analysed during the current study are available from the corresponding author on reasonable request.

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Acknowledgements

This work has been supported by the RF Government Grant No. 075-15-2022-1094 in part of the biophysical interpretation. In the part of the development of numeric method of data analysis, this work has been supported by of the Government Procurement of the Russian Federation Ministry of Healthcare No. 056-00030-21-01 of May 02, 2021 Theoretical and Experimental Study of the Integrative Activity of Various Physiological Systems of Patient under Stress (the State registration number 121030900357-3). The experimental work was carried out with the support of the Ministry of Education and Science of the Russian Federation within the state assignment of Institute of Higher Nervous Activity for 2021–2023.

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Authors and Affiliations

  1. Laboratory of Neuroontogenesis, Institute of Higher Nervous Activity and Neurophysiology of Russian Academy of Sciences, Moscow, 117485, Russia

    Evgenia Sitnikova, Elizaveta Rutskova & Kirill Smirnov

  2. Center for Coordination of Fundamental Scientific Activities, National Medical Research Center for Therapy and Preventive Medicine, Moscow, 101990, Russia

    Anastasiya Runnova & Maksim Zhuravlev

  3. Institute of Cardiological Research, Saratov State Medical University, Saratov, 410005, Russia

    Anastasiya Runnova & Maksim Zhuravlev

  4. Institute of Physics, Saratov State University, Saratov, 410012, Russia

    Anastasiya Runnova & Maksim Zhuravlev

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  1. Evgenia Sitnikova
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Correspondence to Maksim Zhuravlev.

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Sitnikova, E., Rutskova, E., Smirnov, K. et al. Intracortical synchronization pattern on the preclinical and clinical stages of absence epilepsy (analysis of wavelet bicoherence in WAG/Rij rats). Eur. Phys. J. Spec. Top. 232, 583–594 (2023). https://doi.org/10.1140/epjs/s11734-022-00719-y

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