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State of Autonomic Regulation of Heart Rhythm in Young and Old Rats before and after the Application of Different Regimens of Rhythmic Extreme Cooling

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Abstract

The influence of various regimens of rhythmic, extreme cold effects on the state of autonomic regulation of the heart rate was studied in young and old rats. Spectral analysis of heart-rate variability found that the use of rhythmic extreme cold exposures (RECE) with temperature regimens of (–120; –120; –120°С) and (–60; –120; –120°С) significantly increased the body’s adaptive capabilities in young rats due to the activation of their homeostatic regulatory systems. At the same time, the combined RECE regimen (‒60; –120; ‒120°С) appeared to be the most optimal for mature animals, since its use was not accompanied by excessive activation of the sympathoadrenal system at the early stages of experimental studies, in contrast to the regimen (–120; –120; –120°С). In addition, the use of this cooling mode contributed to a statistically significant increase in the total spectral power of neurohumoral regulation due to an increase in the tone of vegetative centers rather than a rise in the activity of the humoral–metabolic regulation link, the prevalence of which is characteristic of old age; thus, the parasympathetic effects on the myocardium prevailed over the sympathetic ones.

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Authors and Affiliations

  1. Institute for Problems of Cryobiology and Cryomedicine, National Academy of Sciences of Ukraine, 61016, Kharkov, Ukraine

    V. V. Kulik & V. G. Babiichuk

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  1. V. V. Kulik
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  2. V. G. Babiichuk
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Correspondence to V. G. Babiichuk.

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Conflict of interest. The authors declare that they have no conflict of interest.

Statement of animal welfare. The experiments were conducted according to the Ukrainian Law On the Protection of Animals from Abuse (no. 3447-IV, February 21, 2006) and following the requirements of the bioethical committee corresponding with the regulations of the European Convention For the Protection of Vertebrate Animals Used for Experimental and Other Scientific Purposes (Strasbourg, 1986).

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Translated by E. Sherstyuk

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Kulik, V.V., Babiichuk, V.G. State of Autonomic Regulation of Heart Rhythm in Young and Old Rats before and after the Application of Different Regimens of Rhythmic Extreme Cooling. Adv Gerontol 11, 113–119 (2021). https://doi.org/10.1134/S2079057021010409

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  • DOI: https://doi.org/10.1134/S2079057021010409

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