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Association between Cytokine Gene Polymorphisms and Breast Cancer in Postmenopausal Women

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Abstract

The goal of this study was to investigate the association between the polymorphic loci of genes IL1B (rs16944), IL1RN (rs4251961), IL6 (rs1800795, rs1800796, rs1554606), IL8 (rs4073), IL10 (rs1800896), and TNFA (rs1800629) and breast cancer in women. The DNA samples of 521 women with breast cancer and 267 women without oncological pathology were studied. The study showed that age, concomitant chronic morbidity, and polymorphism of the IL6 gene are risk factors in postmenopausal women. Allele –572C (OR = 5.68; 95% CI = [2.70–11.97], pcor < 0.001), and haplotype rs1800796[C]–rs1800795[G]–rs1554606[G] (OR = 5.31, 95% CI = [1.87 – 15.10], pcor = 0.002) of the IL6 gene were associated with breast cancer. No association of loci in IL1B (rs16944), IL1RN (rs4251961), IL8 (rs4073), IL10 (rs1800896), or TNFA (rs1800629) was associated with the risk of breast cancer. The obtained data indicate that the –572C allele of the IL6 gene is associated with susceptibility in postmenopausal women to breast cancer. Our results can be useful for an understanding of the molecular mechanisms of breast cancer.

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Funding

This work was carried out within the framework of project VI.59.1.1 of the Program of Fundamental Scientific Research of the Siberian Branch of the Russian Academy of Sciences (state assignment no. 0352-2019-0011).

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Authors and Affiliations

  1. Institute of Human Ecology, Federal Research Center of Coal and Coal Chemistry, Siberian Branch, Russian Academy of Sciences, 650065, Kemerovo, Russia

    L. A. Gordeeva, S. A. Mun, E. G. Polenok & A. N. Glushkov

  2. Institute of Chemical Biology and Fundamental Medicine, Siberian Branch, Russian Academy of Sciences, 630090, Novosibirsk, Russia

    E. N. Voronina, E. A. Sokolova & M. L. Filipenko

  3. Regional Clinical Oncological Dispensary, 650036, Kemerovo, Russia

    N. E. Verzhbitskaya, A. V. Antonov & V. A. Lutsenko

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  1. L. A. Gordeeva
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  4. E. G. Polenok
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  5. E. A. Sokolova
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  6. N. E. Verzhbitskaya
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  7. A. V. Antonov
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  8. V. A. Lutsenko
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Correspondence to L. A. Gordeeva.

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Conflict of interests. The authors declare that they have no conflict of interest.

Statement of compliance with standards of research involving humans as subjects. Before sampling the material (peripheral whole blood), the women gave their voluntary, written, informed consent to participate in the study. The study was conducted confidentially and in accordance with the ethical standards of the 1975 Declaration of Helsinki.

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Translated by K. Lazarev

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Gordeeva, L.A., Mun, S.A., Voronina, E.N. et al. Association between Cytokine Gene Polymorphisms and Breast Cancer in Postmenopausal Women. Adv Gerontol 11, 44–52 (2021). https://doi.org/10.1134/S2079057021010367

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