Abstract
Reverse microemulsions in the lecithin–oleic acid–paraffin oil–avocado oil–tea tree essential oil–water system and lamellar liquid crystals in the lecithin–avocado oil–tea tree essential oil–water system were studied as systems for transdermal drug delivery. Oil- and water-soluble substances, as well as substances that are poorly soluble in water and oil in the form of solid-phase particles, can be introduced into liquid crystals in concentrations of a few percent. Oil-soluble substances can be introduced into reverse microemulsions in concentrations of a few percent and water-soluble substances can be introduced in concentrations of tenths of a percent. The dialysis method showed that the rate of release of water-soluble substances from the reverse microemulsion containing 4.8 wt % water is approximately 2.5 times higher than that from the lamellar liquid crystal containing 15 wt % water. This is explained by the fact that the viscosity of liquid crystals is more than 100 times higher than the viscosity of microemulsions.
Similar content being viewed by others
REFERENCES
Nanotherapeutics: Drug Delivery Concepts in Nanoscience, Ed. by A. Lamprecht (CRC, Boca Raton, FL., 2008; Nauchnyi Mir, Moscow, 2010).
Yu. S. Tarakhovskii, Intelligent Lipid Nanocontainers in Targeted Drug Delivery (LKI, Moscow, 2011) [in Russian].
N. M. Murashova, E. S. Trofimova, and E. V. Yurtov, “Dynamics of scientific publications on the use of nanoparticles and nanostructures for targeted drug delivery,” Nanoindustriya 12, 24 (2019). http://www.nanoindustry.su/journal/article/7238.
N. M. Murashova and E. V. Yurtov, “Lecithin organogels as prospective functional nanomaterial,” Nanotechnol. Russ. 10, 511 (2015). https://doi.org/10.1134/S199507801504014X
A. Zabara and R. Mezzenga, “Controlling molecular transport and sustained drug release in lipid-based liquid crystalline mesophases,” J. Control. Release 188, 31 (2014). https://doi.org/10.1016/j.jconrel.2014.05.052
E. Acosta, O. Chung, and X. Y. Xuang, “Lecithin-linker microemulsions in transdermal delivery,” J. Drug Deliv. Sci. Technol. 21, 77 (2011). https://doi.org/10.1016/S1773-2247(11)50007-3
R. G. Alany, G. El Maghraby, K. Krauel-Goellner, and A. Graf, “Microemulsion systems and their potential as drug carriers,” in Microemulsions: Properties and Applications, Ed. by M. Fanun (CRC, Boca Raton, London, New York, 2008), p. 247.
M. J. Lawrence and G. D. Rees, “Microemulsion-based media as novel drug delivery systems,” Adv. Drug Deliv. Rev. 64 (Suppl.), 175 (2012). https://doi.org/10.1016/j.addr.2012.09.018
M. Fanun, “Microemulsions as delivery systems,” Curr. Opin. Colloid Interface Sci. 17, 306 (2012). https://doi.org/10.1016/j.cocis.2012.06.001
S. P. Callender, J. A. Mathews, K. Kobernyk, and S. D. Wettig, “Microemulsion utility in pharmaceuticals: implications for multi-drug delivery,” Int. J. Pharm. 526, 425 (2017). https://doi.org/10.1016/j.ijpharm.2017.05.005
Ko Jin Young, Kim Ji Yeon, Park So Hyun, et al., “Sustained-release lipid pre-concentrate of pharmacologically active substance and pharmaceutical composition comprising the same,” WO Patent No. 2013/032207 (2013). https://patentscope.wipo.int/search/en/detail.jsf?docId=WO2013032207.
K. Thuresson, F. Tiberg, M. Johansson, et al., “Liquid depot formulations,” WO Patent No. 2005/117830 (2005). https://patentscope.wipo.int/search/en/detail.jsf?docId=WO2005117830.
J. M. Seddon and R. H. Templer, “Polymorphism of lipid-water systems,” in Handbook of Biological Physics, Ed. by R. Lipowsky and E. Sackmann (Elsevier Science, Amsterdam etc., 1995), Vol. 1, p. 97.
R. Angelico, A. Ceglie, G. Colafemmina, et al., “Phase behavior of the lecithin/water/decane systems,” Langmuir 20, 619 (2004). https://doi.org/10.1021/la035603d
Yu. A. Shchipunov, “Self-organising structures of lecithin,” Russ. Chem. Rev. 66, 301 (1997). https://doi.org/10.1070/RC1997v066n04ABEH000253
N. M. Murashova, L. A. Prokopova, E. S. Trofimova, and E. V. Yurtov, “Effects of oleic acid and phospholipids on the formation of lecithin organogel and microemulsion,” J. Surfact. Deterg. 21, 635 (2018). https://doi.org/10.1002/jsde.12170
N. M. Murashova, E. S. Trofimova, and E. V. Yurtov, “Lecithin composition,” RF Patent No. 262250 (2016). http://www1.fips.ru/registers-web/actionćName=clickRegister®Name=RUPAT.
N. M. Murashova, M. Yu. Kostyuchenko, A. N. Bizyukova, and E. V. Yurtov, “Liquid crystal composition for transdermal delivery of biologically active substances,” RF Patent No. 2623210 (2016). http://www1.fips.ru/registers-web/actionćName=clickRegister®Name=RUPAT.
N. M. Murashova, A. A. Dambieva, and E. V. Yurtov, “The effect of nano- and microparticles of iron (III) oxide on the viscosity of lamellar liquid crystals of lecithin,” Izv. Vyssh. Uchebn. Zaved., Khim. Khim. Tekhnol. 59 (5), 41 (2016).
Pharmaceutical Development. Scientific-Practical Guide for the Pharmaceutical Sector, Ed. by S. N. Bykovskii (Pero, Moscow, 2015) [in Russian].
W. R. Kadhum, T. Hada, I. Hijikuro, et al., “Development and optimization of orally and topically applied liquid crystal drug formulations,” J. Oleo Sci. 66, 939 (2017). https://doi.org/10.5650/jos.ess17032
A. Ebenazer, J. S. Franklyne, A. Mukherjee, and N. Chandrasekaran, “Development of azithromycin loaded lemongrass oil based microemulsion and determination of antibacterial potential,” Int. J. Appl. Pharmaceut. 10 (6), 72 (2018). https://doi.org/10.22159/ijap.2018v10i6.25417
Author information
Authors and Affiliations
Corresponding author
Additional information
Translated by O. Kadkin
Rights and permissions
About this article
Cite this article
Murashova, N.M., Trofimova, E.S., Kostyuchenko, M.Y. et al. Microemulsions and Lyotropic Liquid Crystals of Lecithin as Systems for Transdermal Drug Delivery. Nanotechnol Russia 14, 68–73 (2019). https://doi.org/10.1134/S1995078019010075
Received:
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1134/S1995078019010075