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Destruction of the Shell of Influenza Viruses by Heteropoly Acids with Keggin Structure

  • CHEMICAL PHYSICS OF BIOLOGICAL PROCESSES
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Abstract

The results of an electron microscopic study of the effect of heteropoly acids (HPAs) with a Keggin structure on particles of influenza A/Aichi/1/68 (H3N2) and A/California/07/09 (H1N1) pdm09 viruses are presented. It is shown that the action of HPAs on viral particles leads to a complete (or partial) removal of transmembrane glycoproteins and the destruction of matrix protein M1, which manifests itself in the deformations and destruction of viral membranes. Using the A/California/07/09 (H1N1) pdm09 viruses as an example, it is shown that the efficiency of the destruction of the viral envelope by HPAs depends on the medium in which the viruses are cultured. The mechanism of destruction is proposed, which involves the extraction of cholesterol, etching of phospholipids, and the formation of pores in the lipid membrane as a result of the action of heteropolyanions. It is assumed that the penetration of protons through the formed pores can lead to the destruction of the matrix protein M1.

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Funding

This study was carried out as part of a state assignment on topic no. 0082-2018-0003 (registration number AAAA-A18-118012390045-2) “Fundamentals of the creation of a new generation of nanostructured systems with unique operational electrical and magnetic properties” with financial support from the Russian Foundation for Basic Research (grant no. 18-54-00004 Bel_a) and the Belarusian Foundation for Basic Research (agreement no. Х18Р-110).

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Authors and Affiliations

  1. Semenov Federal Research Center for Chemical Physics, Russian Academy of Sciences, Moscow, Russia

    S. A. Kovalevskiy, E. M. Balashov & F. I. Dalidchik

  2. Gamaleya Research Institute of Epidemiology and Microbiology, Moscow, Russia

    O. A. Lopatina, E. A. Gushchina, E. I. Isaeva, I. T. Fedyakina, O. V. Baklanova & M. V. Mezentseva

  3. Institute of General and Inorganic Chemistry, National Academy of Sciences of Belarus, Minsk, Belarus

    N. M. Ivashkevich & A. I. Kulak

Authors
  1. S. A. Kovalevskiy
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  2. O. A. Lopatina
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  3. E. A. Gushchina
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  4. E. I. Isaeva
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  5. I. T. Fedyakina
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  6. O. V. Baklanova
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  7. M. V. Mezentseva
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  8. E. M. Balashov
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  9. N. M. Ivashkevich
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  10. A. I. Kulak
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  11. F. I. Dalidchik
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Corresponding author

Correspondence to E. M. Balashov.

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Kovalevskiy, S.A., Lopatina, O.A., Gushchina, E.A. et al. Destruction of the Shell of Influenza Viruses by Heteropoly Acids with Keggin Structure. Russ. J. Phys. Chem. B 15, 1019–1025 (2021). https://doi.org/10.1134/S1990793121060051

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  • DOI: https://doi.org/10.1134/S1990793121060051

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