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Physicochemical Characteristics and Anticancer Properties of the Liposomal Form of Pyropheophorbide-a Methyl Ester

  • CHEMICAL PHYSICS OF BIOLOGICAL PROCESSES
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Abstract

In order to increase the bioavailability of water-insoluble pyropheophorbide-a (PPP-a) methyl ester, its liposomal form is prepared and the physicochemical and photochemical properties of this form are studied. The quantum yield of 1O2 is found to have a bell-shaped dependence on the concentration of PPP-a in the lipid phase of liposomes with the maximum at 31.6 µmol/g of lipids. The IR spectroscopy shows the photoinduced formation of aldehyde groups in the lipid phase of liposomes. The intracellular accumulation of PPP-a is confirmed by confocal microscopy.

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ACKNOWLEDGMENTS

Spectroscopic measurements were performed at the Center for Shared Use “New Materials and Technology” of the Institute of Biochemical Physics of the Russian Academy of Sciences.

Funding

This study was financially supported by the Russian Science Foundation (project no. 18-13-00463 “Mechanism of Photochemical Processes in the Complexes of Polymethine Dyes with Two Conjugated Chromophores and Proteins”).

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Authors and Affiliations

  1. Emanuel Institute of Biochemical Physics, Russian Academy of Sciences, 119991, Moscow, Russia

    M. A. Klimovich, N. N. Sazhina, A. Sh. Radchenko, N. Yu. Gerasimov, A. E. Egorov, O. V. Nevrova, A. V. Shibaeva, A. O. Shkirdova, V. A. Kuzmin & A. B. Shevelev

  2. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, 119991, Moscow, Russia

    A. A. Markova

  3. Frumkin Institute of Physical Chemistry and Electrochemistry, Russian Academy of Sciences, 119071, Moscow, Russia

    A. O. Shkirdova, E. S. Belyaev & I. A. Zamilatskov

  4. Moscow State University, 119991, Moscow, Russia

    V. V. Spiridonov

Authors
  1. M. A. Klimovich
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  2. N. N. Sazhina
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  3. A. Sh. Radchenko
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  4. N. Yu. Gerasimov
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  5. A. E. Egorov
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  6. O. V. Nevrova
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  7. A. V. Shibaeva
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  8. A. O. Shkirdova
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  9. A. A. Markova
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  10. E. S. Belyaev
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  11. I. A. Zamilatskov
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  12. V. V. Spiridonov
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  13. V. A. Kuzmin
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  14. A. B. Shevelev
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Corresponding author

Correspondence to V. A. Kuzmin.

Additional information

Translated by K. Utegenov

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Klimovich, M.A., Sazhina, N.N., Radchenko, A.S. et al. Physicochemical Characteristics and Anticancer Properties of the Liposomal Form of Pyropheophorbide-a Methyl Ester. Russ. J. Phys. Chem. B 15, 93–102 (2021). https://doi.org/10.1134/S1990793121010206

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  • DOI: https://doi.org/10.1134/S1990793121010206

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