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Influence of small-molecule ligands and their complexes on lysozyme properties

  • Chemical Physics of Biological Processes
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Abstract

The structure of complexes of various alkylhydroxybenzenes, such as 4-hexylresorcinol, 5-methyl-resorcinol, and tyrosol, is studied using experimental and theoretical methods. The influence of 4-hexyl-resorcinol and 5-methylresorcinol in a wide range of concentrations on the structure, equilibrium fluctuations, and functional activity of a water-soluble enzyme lysozyme is examined. A spatial model for the interaction of ligands and clusters thereof with the protein and the aqueous medium is constructed. A possible mechanism of the stabilization of the protein tertiary structure by the aforementioned molecules is proposed.

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Authors and Affiliations

  1. Semenov Institute of Chemical Physics, Russian Academy of Sciences, Moscow, Russia

    K. B. Tereshkina, A. S. Stepanov, D. O. Sinitsyn & Yu. F. Krupyanskii

Authors
  1. K. B. Tereshkina
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  2. A. S. Stepanov
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  3. D. O. Sinitsyn
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  4. Yu. F. Krupyanskii
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Correspondence to Yu. F. Krupyanskii.

Additional information

Original Russian Text © K.B. Tereshkina, A.S. Stepanov, D.O. Sinitsyn, Yu.F. Krupyanskii, 2014, published in Khimicheskaya Fizika, 2014, Vol. 33, No. 7, pp. 64–73.

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Tereshkina, K.B., Stepanov, A.S., Sinitsyn, D.O. et al. Influence of small-molecule ligands and their complexes on lysozyme properties. Russ. J. Phys. Chem. B 8, 534–542 (2014). https://doi.org/10.1134/S1990793114040137

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  • DOI: https://doi.org/10.1134/S1990793114040137

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