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Alcohol Withdrawal Leads to an Increase in the CRFR2 mRNA Level in the Ventricular Tegmental Region of the Rat Brain

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Abstract—

Ethanol withdrawal causes impairments in brain neurotransmitter systems. This causes pathological craving for alcohol. It is suggested that the type 2 corticotropin-releasing factor receptor (CRFR2) is involved in the mechanism of alcohol craving. This study has shown that during alcohol withdrawal, the level of CRFR2 mRNA in the ventral tegmental region of the brain significantly increased on day 7 of alcohol withdrawal in comparison with the control group. This suggests possible involvement of CRFR2 in the modulation of dopaminergic and GABAergic neurons in the ventral tegmental region of the brain.

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Authors and Affiliations

  1. Institute of Experimental Medicine, ul. Akad. Pavlova 12, 197376, St. Petersburg, Russia

    M. I. Airapetov, E. A. Sekste, A. A. Lebedev, E. R. Bychkov & P. D. Shabanov

  2. St. Petersburg State Medical Pediatric University, ul. Litovskaya 2, 194100, St. Petersburg, Russia

    M. I. Airapetov

  3. ITMO University, Kronverkskiy pr. 49, 197101, St. Petersburg, Russia

    S. O. Eresko

  4. Kirov Military Medical Academy, ul. Akad. Lebedeva 6, 194044, St. Petersburg, Russia

    P. D. Shabanov

Authors
  1. M. I. Airapetov
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  2. S. O. Eresko
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  3. E. A. Sekste
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  4. A. A. Lebedev
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  5. E. R. Bychkov
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  6. P. D. Shabanov
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Corresponding author

Correspondence to M. I. Airapetov.

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All methods used in this study were approved by the Ethics Committee for the Care and Use of Animals of the Institute of Experimental Medicine (protocol no. 21/15 of February 26, 2015)

The authors declare that they have no conflict of interest.

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Translated by A. Medvedev

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Airapetov, M.I., Eresko, S.O., Sekste, E.A. et al. Alcohol Withdrawal Leads to an Increase in the CRFR2 mRNA Level in the Ventricular Tegmental Region of the Rat Brain. Biochem. Moscow Suppl. Ser. B 14, 20–22 (2020). https://doi.org/10.1134/S1990750820010035

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  • DOI: https://doi.org/10.1134/S1990750820010035

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