Abstract
The effect of sulfated polysaccharide fucoidan from the brown alga Laminaria japonica on morphological characteristics of lymphoid organs, subpopulations of spleen mononuclear leukocytes, cytokine production and cytotoxic activity of mouse splenocytes has been investigated. It was found that fucoidan promoted activation of hemopoiesis and proliferation of lymphoid cells in primary and secondary immunogenesis bodies, increased expression of the markers CD19, NK, NKT, CD25, MHC II, TCR, TLR2 and TLR4, the cytotoxic activity of splenocytes and production of immunoregulatory and inflammatory cytokines (IL-2, IL-12, IFN-γ, TNF-α, IL-6); this suggests activation of effector mechanisms of innate immunity and the development of Th-1 type adaptive immune responses.
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Original Russian Text © E.A. Lebedynskaya, I.D. Makarenkova, O.V. Lebedynskaya, N.K. Akhmatova, T.N. Zvyagintseva, 2015, published in Biomeditsinskaya Khimiya.
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Lebedynskaya, E.A., Makarenkova, I.D., Lebedynskaya, O.V. et al. The effect of sulfated polysaccharides from brown seaweed Laminaria japonica on the morphology of lymfoid organs and functional characteristics of immunocompetent cells. Biochem. Moscow Suppl. Ser. B 9, 86–94 (2015). https://doi.org/10.1134/S1990750815010060
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DOI: https://doi.org/10.1134/S1990750815010060