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Pathogenesis of insulin resistance in metabolic obesity

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Abstract

This review considers molecular mechanisms of insulin resistance developed under conditions of metabolic inflammation; special attention is paid to analysis of the results of experimental and clinical studies work aimed at identifying molecular targets for the development of new methods for prevention and treatment of insulin resistance.

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References

  1. Hirabara, S.M., Gorjão, R., Vinolo, M.A., Rodrigues, A.C., Nachbar, R.T., and Curi R., J. Biomed. Biotechnol., 2012, vol. 2012, ID 379024.

  2. Tron’ko, N.D., Kovzun, E.I., and Pushkarev, V.M., Zhurn. Ukr. Nat. Akad. Med. Nauk, 2012, vol. 18, no. 4, pp. 430–439.

    Google Scholar 

  3. Burks, D.J. and White, M.F., Diabetes, 2001, vol. 50, pp. 140–145.

    Google Scholar 

  4. Durmu Tekir, S., Ümit P., Toku, E.A., and Ülgen, K.O., J. Biomed. Biotechnol., 2010, vol. 2010, ID 690925.

  5. Thirone, A.C., Huang, C., and Klip, A., Trends Endocrinol. Metab., 2006, vol. 17, pp. 72–78.

    Google Scholar 

  6. Thong, F.S.L., Dugani, C.B., and Klip, A., Physiology, 2005, vol. 4, pp. 271–284.

    Google Scholar 

  7. Sharma, M.D., Garber, A.J., and Farmer, J.A., Endocr. Pract., 2008, vol. 14, pp. 373–380.

    Google Scholar 

  8. Mitra, P., Zheng, X., and Czech, M.P., J. Biol. Chem., 2004, vol. 279, pp. 37431–37435.

    CAS  Google Scholar 

  9. Chang, L., Chiang, S., and Saltiel, A.R., Mol. Med., 2004, vol. 10, nos. 7–12, pp. 65–71.

    CAS  Google Scholar 

  10. Skolnik, E.Y., Batzer, A., Li, N., Lee, C.H., Lowenstein, E., Mohammadi, M., Margolis, B., and Schlessinger, J., Science, 1993, vol. 260, no. 5116, pp. 1953–1955.

    CAS  Google Scholar 

  11. Gureasko, J., Galush, W.J., Boykevisch, S., Sondermann, H., Bar-Sagi, D., Groves, J.T., and Kuriyan, J., Nat. Struct. Mol. Biol., 2008, vol. 15, pp. 452–461.

    CAS  Google Scholar 

  12. Combettes-Souverain, M. and Issad, T., Diabetes Metab., 1998, vol. 24, pp. 477–489.

    CAS  Google Scholar 

  13. Somwar, R., Kim, D.Y., Sweeney, G., Huang, C., Niu, W., Lador, C., Ramlal, T., and Klip, A., Biochem. J., 2001, vol. 359, pp. 639–649.

    CAS  Google Scholar 

  14. Rains, J.L. and Jain, S.K., Free Radic. Biol. Med., 2011, vol. 50, pp. 567–575.

    CAS  Google Scholar 

  15. Henriksen, E.J., Diamond-Stanic, M.K., and Marchionne, E.M., Free Radic. Biol. Med., 2011, vol. 51, pp. 993–999.

    CAS  Google Scholar 

  16. Kontrogianni-Konstantopoulos, A., Benian, G., and Granzier, H., J. Biomed. Biotechnol., 2012, vol. 2012, ID 930836.

  17. Martins, A.R., Nachbar, R.T., Gorjao, R., Vinolo, M.A., Festuccia, W.T., Lambertucci, R.H., Cury-Boaventura, M.F., Silveira, L.R., Curi, R., and Hirabara, S.M., Lipids Health Dis., 2012, vol. 11, p. 30.

    CAS  Google Scholar 

  18. Newsholme, P., Haber, E.P., Hirabara, S.M., Rebelato, E.L., Procopio, J., Morgan, D., Oliveira-Emilio, H.C., Carpinelli, A.R., and Curi, R., J. Physiol., 2007, vol. 583, pp. 9–24.

    CAS  Google Scholar 

  19. Brehm, A., Krssak, M., Schmid, A.I., Nowotny, P., Waldhäusl, W., and Roden, M., Diabetes, 2006, vol. 55, pp. 136–140.

    CAS  Google Scholar 

  20. Lenoir, O., Flosseau, K., Ma, F.X., Blondeau, B., Mai, A., Bassel-Duby, R., Ravassard, P., Olson, E.N., Haumaitre, C., and Scharfmann, R., Diabetes, 2011, vol. 60, pp. 2861–2871.

    CAS  Google Scholar 

  21. Rajendran, R., Garva, R., Krstic-Demonacos, M., and Demonacos, C., J. Biomed. Biotechnol., 2011, vol. 2011, ID 368276.

  22. Bashan, N., Kovsan, J., Kachko, I., Ovadia, H., and Rudich, A., Physiol. Rev., 2009, vol. 89, pp. 27–71.

    CAS  Google Scholar 

  23. Zhang, L., Haraguchi, S., Koda, T., Hashimoto, K, and Nakagawara, A., J. Biomed. Biotechnol., 2011, vol. 2011, ID 831092.

  24. Pankratova, M.A., Pirozhkov, S.V., Balabolkin, M.I., and Levitzkii, P.F., Sakharnyi Diabet, 2006, no. 2, pp. 12–15.

    Google Scholar 

  25. Laybutt, D.R., Kaneto, H., Hasenkamp, W., Grey, S., Jonas, J.C., Sgroi, D.C., Groff, A., Ferran, C., Bonner-Weir, S., Sharma, A., and Weir, G.C., Diabetes, 2002, vol. 51, pp. 413–423.

    CAS  Google Scholar 

  26. Schwartz, V., Ter. Arkhiv, 2009, no. 10, pp. 74–80.

    Google Scholar 

  27. Fernandez-Real, J.M. and Ricart, W., Endocr. Rev., 2004, vol. 24, pp. 278–301.

    Google Scholar 

  28. Schwartz, V., Kardiologiya, 2009, no. 12, pp. 80–86.

    Google Scholar 

  29. Medzhitov, R., Nature, 2008, vol. 454, no. 7203, pp. 428–435.

    CAS  Google Scholar 

  30. Mathis, D., Cell. Metab., 2013, vol. 17, pp. 851–859.

    CAS  Google Scholar 

  31. Kulikov, D.I., Vasilenko, M.A., Kirienkova, E.V., Mazunin, I.O., Zatolokin, P.A., and Litvinova, L.S., Kant Baltic Federal University Vestnik, 2013, vol. 4, pp. 51–56.

    Google Scholar 

  32. Hotamisligil, G.S., Nature, 2006, vol. 444, no. 7121, pp. 860–867.

    CAS  Google Scholar 

  33. Fuentes, E., Fuentes, F., Vilahur, G., Badimon, L., and Palomo, I., Mediators Inflamm., 2013, vol. 2013, ID 136584.

  34. Ellingsgaard, H., Hauselmann, I., Schuler, B., Habib, A.M., Baggio, L.L., Meier, D.T., Eppler, E., Bouzakri, K., Wueest, S., Muller, Y.D., Hansen, A.M., Reinecke, M., Konrad, D., Gassmann, M., Reimann, F., Halban, P.A., Gromada, J., Drucker, D.J., Gribble, F.M., Ehses, J.A., and Donath, M.Y., Nat. Med., 2011, vol. 17, pp. 1481–1489.

    CAS  Google Scholar 

  35. Donath, M.Y., Dalmas, é., Sauter, N.S., Böni-Schnetzler, M., Cell Metab., 2013, vol. 17, pp. 860–872.

    CAS  Google Scholar 

  36. Turu, M.M., Slevin, M., Matou, S., West, D., Rodríguez, C., Luque, A., Grau-Olivares, M., Badimon, L., Martinez-Gonzalez, J., and Krupinski, J., BMC Cell. Biol., 2008, vol. 9, p. 47.

    Google Scholar 

  37. Kirienkova, E.V., Litvinova, L.S., Seledtsov, V.I., Zatolokin, P.A., and Aksenova, N.N., Klin. Labor. Diagn., 2012, no. 12, pp. 3–5.

    Google Scholar 

  38. Litvinova, L.S., Zatolokin, P.A., Poznyak, E.V., Seledtsova, I.A., Kirienkova, E.V., and Seledtsova, V.I., Annaly Khirurgii, prilozhenie 1, 2011, pp. 39–40.

    Google Scholar 

  39. Sun, K., Kusminski, C.M., and Scherer, P.E., J. Clin. Invest., 2011, vol. 121, no. 6, pp. 2094–2101.

    CAS  Google Scholar 

  40. Aderem, A. and Ulevitch, R.J., Nature, 2000, vol. 406, no. 6797, pp. 782–787.

    CAS  Google Scholar 

  41. Dasu, M.R., Devaraj, S., Park, S., and Jialal, I., Diabetes Care, 2010, vol. 33, no. 4, pp. 861–868.

    CAS  Google Scholar 

  42. Kim, H.S., Han, M.S., Chung, K.W., Kim, S., Kim, E., Kim, M.J., Jang, E., Lee, H.A., Youn, J., Akira, S., and Lee, M.S., Immunity, 2007, vol. 27, no. 2, pp. 321–333.

    CAS  Google Scholar 

  43. Kopp, A., Buechler, C., Bala, M., Neumeier, M., Schölmerich, J., and Schäffler, A., Endocrinology, 2010, vol. 151, pp. 1097–1108.

    CAS  Google Scholar 

  44. Haversen, L., Danielsson, K.N., Fogelstrand, L., and Wiklund, O., Atherosclerosis, 2009, vol. 202, pp. 382–393.

    CAS  Google Scholar 

  45. Wen, H., Gris, D., Lei, Y., Jha, S., Zhang, L., Huang, M.T., Brickey, W.J. and Ting, J.P., Nat. Immunol., 2011, vol. 12, pp. 408–415.

    CAS  Google Scholar 

  46. Rydén, M., Dicker, A., Van Harmelen, V., Hauner, H., Brunnberg, M., Perbeck, L., Lonnqvist, F., and Arner, P., J. Biol. Chem., 2002, vol. 277, pp. 1085–1091.

    Google Scholar 

  47. Ye, J., Gao, Z., Yin, J., and He, Q., Am. J. Physiol. Endocrinol. Metab., 2007, vol. 293, pp. 1118–1128.

    Google Scholar 

  48. Davis, H.M., Carpenter, D.C., Stahl, J.M., Zhang, W., Hynicka, W.P., and Griswold, D.E., J. Immunol. Methods, 2000, vol. 240, pp. 125–132.

    CAS  Google Scholar 

  49. Deopurkar, R., Ghanim, H., Friedman, J., Abuaysheh, S., Sia, C.L., Mohanty, P., Viswanathan, P., Chaudhuri, A., and Dandona, P., Diabetes Care, 2010, vol. 33, no. 5, pp. 991–997.

    CAS  Google Scholar 

  50. Yan, S.F., Ramasamy, R., and Schmidt, A.M., J. Mol. Med. (Berl.), 2009, vol. 87, no. 3, pp. 235–247.

    CAS  Google Scholar 

  51. Zhou, R., Tardivel, A., Thorens, B., Choi, I., and Tschopp, J., Nat. Immunol., 2010, vol. 11, pp. 136–140.

    CAS  Google Scholar 

  52. Böni-Schnetzler, M., Boller, S., Debray, S., Bouzakri, K., Meier, D.T., Prazak, R., Kerr-Conte, J., Pattou, F., Ehses, J.A., Schuit, F.C., and Donath, M.Y., Endocrinology, 2009, vol. 150, pp. 5218–5229.

    Google Scholar 

  53. Peppa, M., Koliaki, C., Nikolopoulos, P., ad Raptis, S.A., J. Biomed. Biotechnol., 2010, vol. 2010, ID 527850.

  54. Schwartz, V., Probl. Endokrinol., 2009, vol. 55, no. 1, pp. 38–44.

    Google Scholar 

  55. Mothe-Satney, I., Filloux, C., Amghar, H., Pons, C., Bourlier, V., Galitzky, J., Grimaldi, P.A., Féral, C.C., Bouloumié, A., Van Obberghen, E., and Neels, J.G., Diabetes, 2012, vol. 61, no. 9, pp. 2311–2319.

    CAS  Google Scholar 

  56. Kurokaw, J., Nagano, H., Ohara, O., Kubota, N., Kadowaki, T., Arai, S., and Miyazaki, T., Proc. Natl. Acad. Sci. USA, 2011, vol. 108, pp. 12072–12077.

    Google Scholar 

  57. Yang, H., Youm, Y.H., Vandanmagsar, B., Ravussin, A., Gimble, J.M., Greenway, F., Stephens, J.M., Mynatt, R.L., and Dixit, V.D., J. Immunol., 2010, vol. 185, pp. 1836–1845.

    CAS  Google Scholar 

  58. Feuerer, M., Herrero, L., Cipolletta, D., Naaz, A., Wong, J., Nayer, A., Lee, J., Goldfine, A.B., Benoist, C., Shoelson, S., and Mathis, D., Nat. Med., 2009, vol. 15, pp. 930–939.

    CAS  Google Scholar 

  59. Rocha, V.Z., Folco, E.J., Sukhova, G., Shimizu, K., Gotsman, I., Vernon, A.H., and Libby, P., Circ. Res., 2008, vol. 103, pp. 467–476.

    CAS  Google Scholar 

  60. Bertola, A., Ciucci, T., Rousseau, D., Bourlier, V., Duffaut, C., Bonnafous, S., Blin-Wakkach, C., Rodolphe, A.A., Gugenheim, I.J., Tran, A.B., and Wakkach, P.G., Diabetes, 2012, vol. 61, pp. 2238–2247.

    CAS  Google Scholar 

  61. Mandal, P., Pratt, B.T., Barnes, M., McMullen, M.R., and Nagy, L.E., J. Biol. Chem., 2011, vol. 286, pp. 13460–13469.

    CAS  Google Scholar 

  62. Zamboni, M., Di Francesco, V., Garbin, U., Fratta Pasini, A., Mazzali, G., Stranieri, C., Zoico, E., Fantin, F., Bosello, O., and Cominacini, L., Int. J. Obes. (Lond.), 2007, vol. 31, pp. 1104–1109.

    CAS  Google Scholar 

  63. Litvinova, L.S., Kirienkova, E.V., Aksenova, N.N., Zatolokin, P.A., and Gazatova, N.D., Byull. Sib. GMU, 2012, vol. 3, pp. 53–58.

    Google Scholar 

  64. Litvinova, L.S., Kirienkova, E.V., Gazatova, N.D., Zatolokin, P.A., Vasilenko, M.A., Simbirtsev, M.A., and Aksenova, N.N., Tsitokiny i Vospalenie, 2013, vol. 12, no. 3, pp. 62–67.

    Google Scholar 

  65. Ofei, F., Hurel, S., Newkirk, J., Sopwith, M., and Taylor, R., Diabetes, 1996, vol. 45, pp. 881–885.

    Google Scholar 

  66. Gonzalez-Gay, M.A., De Matias, J.M., Gonzalez-Juanatey, C., Garcia-Porrua, C., Sanchez-Andrade, A., Martin, J., and Llorca, J., Clin. Exp. Rheumatol., 2006, vol. 24, pp. 83–86.

    CAS  Google Scholar 

  67. Gonzalez-Gay, M.A., Gonzalez-Juanatey, C., Vazquez-Rodriguez, T.R., Miranda-Filloy, J.A., and Llorca, J., Ann. N-Y Acad. Sci., 2010, vol. 1193, pp. 153–159.

    CAS  Google Scholar 

  68. Stagakis, I., Bertsias, G., Karvounaris, S., Kavousanaki, M., Virla, D., Raptopoulou, A., Kardassis, D., Boumpas, D.T., and Sidiropoulos, P.I., Arthritis Res. Ther., 2012, vol. 14, p. R 141.

    CAS  Google Scholar 

  69. Ridker, P.M., Thuren, T., Zalewski, A., and Libby, P., Am. Heart J., 2011, vol. 162, no. 4, pp. 597–605.

    CAS  Google Scholar 

  70. Cho, H., Black, S.C., Looper, D., Shi, M., Kelly-Sullivan, D., Timofeevski, S., Siegel, K., Yu, X.H., McDonnell, S.R., Chen, P., Yie, J., Kathleen, M.O., Fraser, J., and Briscoe, C.P., Am. J. Physiol. Endocrinol. Metab., 2008, vol. 295, pp. 1142–1151.

    Google Scholar 

  71. Stebbins, J.L., De, S.K., Machleidt, T., Becattini, B., Vazquez, J., Kuntzen, C., Chen, L.H., Cellitti, J.F., Riel-Mehan, M., Emdadi, A., Solinas, G., Karin, M., and Pellecchia, M., Proc. Natl. Acad. Sci. USA, 2008, vol. 105, pp. 16809–16813.

    CAS  Google Scholar 

  72. Ramos-Zavala, M.G., González-Ortiz, M., Martínez-Abundis, E., Robles-Cervantes, J.A., González-López, R., and Santiago-Hernández, N.J., Diabetes Care, 2011, vol. 34, pp. 1591–1594.

    CAS  Google Scholar 

  73. Pavlatou, M.G., Mastorakos, G., Margeli, A., Kouskouni, E., Tentolouris, N., Katsilambros N., Chrousos, G.P., and Papassotiriou, I., Eur. J. Clin. Invest., 2011, vol. 41, pp. 652–658.

    CAS  Google Scholar 

  74. Fujisaka, S., Usui, I., Kanatani, Y., Ikutani, M., Takasaki, I., Tsuneyama, K., Tabuchi, Y., Bukhari, A., Yamazaki, Y., Suzuki, H., Senda, S., Aminuddin, A., Nagai, Y., Takatsu, K., Kobayashi, M., and Tobe, K., Endocrinology, 2011, vol. 152, pp.1789–1799.

    CAS  Google Scholar 

  75. Van der Zijl, N.J., Moors, C.C., Goossens, G.H., Blaak, E.E., and Diamant, M., Diabetes Obes. Metab., 2012, vol. 14, p. 586–595.

    Google Scholar 

  76. Yu, A.M., Expert Opin. Drug. Metab. Toxicol., 2009, vol. 5, pp. 1513–1528.

    CAS  Google Scholar 

  77. Garcia-Guerra, L., Nieto-Vazquez, I., Vila-Bedmar, R., Jurado-Pueyo, M., Zalba, G., Díez, J., Murga, C., Fernández-Veled, S., Mayor, F., Jr., and Lorenzo, M., Diabetes, 2010, vol. 59, pp. 2407–2417.

    CAS  Google Scholar 

  78. Luan, B., Zhao, J., Wu, H., Duan, B., Shu, G.W., Wang, X.Y., Li, D., Jia, W., Kang, J., and Pei, G., Nature, 2009, vol. 457, pp. 1146–1150.

    CAS  Google Scholar 

  79. Hotamisligil, G.S., Shargill, N.S., and Spiegelman, B.M., Science, 1993, vol. 259, vol. 5091, pp. 87–91.

    CAS  Google Scholar 

  80. Feng, X., Wang, W., Liu, J., and Liu, Y., Mol. Biol. Rep., 2011, vol. 38, pp. 2517–2528.

    CAS  Google Scholar 

  81. Mayor, F., Jr., Lucas, E., Jurado-Pueyo, M., Garcia-Guerra, L., Nieto-Vazquez, I., Vila-Bedmar, R., Fernández-Veledo, S., and Murga, C., Arch. Physiol. Biochem., 2011, vol. 117, pp. 125–130.

    CAS  Google Scholar 

  82. Vinolo, M.A., Hirabara, S.M., and Curi, R., Curr. Opin. Clin. Nutr. Metab. Care, 2012, vol. 15, pp. 112–116.

    CAS  Google Scholar 

  83. Tuo, Y., Feng, D.D., Wang, D.-F., Sun, J., Li, S.-B., and Chen, C., Clin. Exp. Pharmacol. Physiol., 2012, vol. 39, pp. 423–428.

    CAS  Google Scholar 

  84. Chu, Z.L., Jones, R.M., He, H., Carroll, C., Gutierrez, V., Lucman, A., Moloney, M., Gao, H., Mondala, H., Bagnol, D., Unett, D., Liang, Y., Demarest, K., Semple, G., Behan, D.P., and Leonard, J., Endocrinology, 2007, vol. 148, pp. 2601–2609.

    CAS  Google Scholar 

  85. Edfalk, S., Steneberg, P., and Edlund, H., Diabetes, 2008, vol. 57, pp. 2280–2287.

    CAS  Google Scholar 

  86. Hansen, K.B., Rosenkilde, M.M., Knop, F.K., Wellner, N., Diep, T.A., Rehfeld, J.F., Andersen, U.B., Holst, J.J., and Hansen, H.S., J. Clin. Endocrinol. Metab., 2011, vol. 96, pp. 1409–1417.

    Google Scholar 

  87. Oh, D.Y., Talukdar, S., Bae, E.J., Imamura, T., Morinaga, H., Fan, W., Li, P., Lu, W.J., Watkins, S.M., and Olefsky, J.M., Cell, 2010, vol. 142, pp. 687–698.

    CAS  Google Scholar 

  88. Glodak, M.A., Sengupta, N., Zhang, X., and Seto, E., Gene, 2005, vol. 363, pp. 15–23.

    Google Scholar 

  89. Grabiec, A.M., Tak, P.P., and Reedquist, K.A., Crit. Rev. Immunol., 2011, vol. 31, pp. 233–263.

    CAS  Google Scholar 

  90. Christensen, D.P., Dahllöf, M., Lundh, M., Rasmussen, D.N, Nielsen, M.D., Billestrup, N., Grunnet, L.G., and Mandrup-Poulsen, T., Mol. Med., 2011, vol. 17, pp. 378–390.

    CAS  Google Scholar 

  91. Lewis, E.C., Blaabjerg, L., Størling, J., Ronn, S.G., Mascagni, P., Dinarello, C.A., and Mandrup-Poulsen, T., Mol. Med., 2011, vol. 17, pp. 369–377.

    CAS  Google Scholar 

  92. Winkler, R., Benz, V., Clemenz, M., Bloch, M., Foryst-Ludwig, A., Wardat, S., Witte, N., Trappiel, M., Namsolleck, P., Mai, K., Spranger, J., Matthias, G., Roloff, T., Truee, O., Kappert, K., Schupp, M., Matthias, P., and Kintscher, U., Diabetes, 2012, vol. 61, 513–523.

    CAS  Google Scholar 

  93. Fuentes, E., Guzmán-Jofre, L., Moore-Carrasco, R., and Palomo, I., Mol. Med. Rep., 2013, vol. 8, pp. 1611–1616.

    CAS  Google Scholar 

  94. Chiarelli, F. and Di Marzio, D., Vasc. Health Risk. Manag., 2008, vol. 4, pp. 297–304.

    CAS  Google Scholar 

  95. Odegaard, J.I., Ricardo-Gonzalez, R.R., Goforth, M.H., Morel, C.R., Subramanian, V., Mukundan, L., Red Eagle, A., Vats, D., Brombacher, F., Ferrante, A.W., and Chawla, A., Nature, 2007, vol. 447, no. 7148, pp. 1116–1120.

    CAS  Google Scholar 

  96. Cipolletta, D., Feuerer, M., Li, A., Kamei, N., Lee, J., Shoelson, S.E., Benoist, C., and Mathis, D., Nature, 2012, vol. 486, no. 7404, pp. 549–553.

    CAS  Google Scholar 

  97. Sugii, S. and Evans, R.M., FEBS Letts., 2011, vol. 585, no. 13, pp. 2121–2128.

    CAS  Google Scholar 

  98. Serhan, C.N., Hong, S., Gronert, K., Colgan, S.P., Devchand, P.R., Mirick, G., and Moussignac, R.L., J. Exp. Med., 2002, vol. 196, pp. 1025–1037.

    CAS  Google Scholar 

  99. Clish, C.B., O’Brien, J.A., Gronert, K., Stahl, G.L., Petasis, N.A., and Serhan, C.N., Proc. Natl. Acad. Sci. USA, 1999, vol. 96, pp. 8247–8252.

    CAS  Google Scholar 

  100. Mukherjee, P.K., Marcheselli, V.L., Barreiro, S., Hu, J., Bok, D., and Bazan, N.G., Proc. Natl. Acad. Sci. USA, 2007, vol. 104, pp. 13152–13157.

    CAS  Google Scholar 

  101. Titos, E., Rius, B., González-Périz, A., López-Vicario, C., Morán-Salvador, E., Martínez-Clemente, M., Arroyo, V., and Clària, J., J. Immunol., 2011, vol. 187, pp. 5408–5418.

    CAS  Google Scholar 

  102. González-Périz, A., Horrillo, R., Ferré, N., Gronert, K., Dong, B., Morán-Salvador, E., Titos, E., Martínez-Clemente, M., López-Parra, M., Arroyo, V., and Clària, J., FASEB J., 2009, vol. 23, pp. 1946–1957.

    Google Scholar 

  103. White, P.J., Arita, M., Taguchi, R., Kang, J.X., and Marette, A., Diabetes, 2010, vol. 59, pp. 3066–3073.

    CAS  Google Scholar 

  104. Horrillo, R., González-Périz, A., Martínez-Clemente, M., López-Parra, M., Ferré, N., Titos, E., Morán-Salvador, E., Deulofeu, R., Arroyo, V., and Clària, J., J. Immunol., 2010, vol. 184, pp. 3978–3987.

    CAS  Google Scholar 

  105. Hellmann, J., Tang, Y., Kosuri, M., Bhatnagar, A., and Spite, M., FASEB J., 2011, vol. 25, pp. 2399–2407.

    CAS  Google Scholar 

  106. Yu, C., Chen, Y., Cline, G.W., Zhang, D., Zong, H., Wang, Y., Bergeron, R., Kim, J.K., Cushman, S.W., Cooney, G.J., Atcheson, B., White, M.F., Kraegen, E.W., and Shulman, G.I., J. Biol. Chem., 2002, vol. 277, pp. 50230–50236.

    CAS  Google Scholar 

  107. Underbayev, C., Kasar, S., Yuan, Y., and Raveche, E., J. Biomed. Biotechnol., 2012, vol. 2012, ID 758169.

  108. Xie, H., Lim, B., and Lodish, H.F., Diabetes, 2009, vol. 58, pp. 1050–1057.

    CAS  Google Scholar 

  109. Frost, R.-J.A. and Olson, E.N., Proc. Natl. Acad. Sci. USA, 2011, vol. 108, pp. 21075–21080.

    CAS  Google Scholar 

  110. Foley, N.H. and O’Neill, L.A., J. Leukoc. Biol., 2012, vol. 92, pp. 521–527.

    CAS  Google Scholar 

  111. Hennessy, E.J., Sheedy, F.J., Santamaria, D., Barbacid, M., and O’Neill, A.J., J. Biol. Chem., 2011, vol. 286, pp. 25531–25539.

    CAS  Google Scholar 

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Authors and Affiliations

  1. Immanuel Kant Baltic Federal University, ul. Botkina 3, Kaliningrad, 236016, Russia

    L. S. Litvinova, E. V. Kirienkova, I. O. Mazunin, M. A. Vasilenko & N. S. Fattakhov

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  1. L. S. Litvinova
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  2. E. V. Kirienkova
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  3. I. O. Mazunin
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  4. M. A. Vasilenko
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  5. N. S. Fattakhov
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Correspondence to L. S. Litvinova.

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Original Russian Text © L.S. Litvinova, E.V. Kirienkova, I.O. Mazunin, M.A. Vasilenko, N.S. Fattakhov, 2014, published in Biomeditsinskaya Khimiya.

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Litvinova, L.S., Kirienkova, E.V., Mazunin, I.O. et al. Pathogenesis of insulin resistance in metabolic obesity. Biochem. Moscow Suppl. Ser. B 8, 192–202 (2014). https://doi.org/10.1134/S1990750814030093

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  • DOI: https://doi.org/10.1134/S1990750814030093

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