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Metabolic Plasticity in Developing and Aging Brain

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Abstract—Brain plasticity is a fundamental phenomenon based on various types of intercellular interactions (synaptic activity, neuritogenesis, synaptogenesis and elimination of synapses, and neuron-glia interactions), development, differentiation, migration of newly-born cells and cell death (neurogenesis/gliogenesis and neuronal or glial cell death, angiogenesis and regression of cerebral microvessels), and adaptation of tissue metabolism to changing environmental conditions. In this review, we discuss our own data and available literature in the context of regulation of certain types of energy metabolism (glycolysis and mitochondrial respiration) in neuronal, glial, and endothelial cells, the signaling functions of metabolites in nervous tissue, and the mechanisms of establishment of cerebral insulin resistance, pseudohypoxia, and associated neuroinflammation in brain pathology, as well as some prospects for detecting novel molecular markers of pathobiochemical processes associated with impaired metabolic plasticity in the developing and aging brain.

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ACKNOWLEDGMENTS

In Krasnoyarsk, the development of research in the field of cellular and molecular mechanisms of the pathology of the nervous system would have been impossible without Professor Valery Vasilievich Ivanov (1947–1998), the founder of the Krasnoyarsk school of pathophysiologists. The author expresses her gratitude to the leading neurobiologist and neurophysiologist, Professor Haruhiro Higashida (Japan), as well as to her alumni, whose experimental studies in 2000–2022 made a significant contribution to the study of the fundamental mechanisms of brain plasticity in normal and pathological conditions (Dr. Sci. (Med.) N.A. Malinovskaya, Dr. Sci. (Med.) A.V. Morgun, Dr. Sci. (Med.) Yu.K. Komleva, Dr. Sci. (Biol.) O.L. Lopatina, Cand. Sci. (Med.) A.N. Shuvaev, Cand. Sci. (Biol.) Ya.V. Gorina, Cand. Sci. (Med.) Yu.A. Panina, E.D. Khilazheva, Dr. Sci. (Biol.) Yu.A. Uspenskaya, Cand. Sci. (Biol.) E.A. Teplyashina, A.I. Mosyagina, Cand. Sci. (Pharm.) E.V. Kharitonova, Cand. Sci. (Biol.) A.A. Semenova, E.V. Lychkovskaya, Cand. Sci. (Biol.) E.A. Pozhilenkova, Cand. Sci. (Pharm.) N.V. Pisareva, Cand. Sci. (Med.) A.I. Chernykh, Cand. Sci. (Med.) O.S. Okuneva, Cand. Sci. (Biol.) V. A. Kutyakov, Cand. Sci. (Biol.) N.S. Shapoval, Cand. Sci. (Med.) N.A. Yauzina, Cand. Sci. (Med.) A.I. Inzhutova and others).

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  1. Research Center of Neurology, Moscow, Russia

    A. B. Salmina

  2. Voino-Yasenetsky Krasnoyarsk State Medical University, Krasnoyarsk, Russia

    A. B. Salmina

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  1. A. B. Salmina
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Dedicated to the memory of Professor V.V. Ivanov

Corresponding author; address: Volokolamskoe shosse 80, Moscow, 125367 Russia; e-mail: allasalmina@mail.ru.

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Salmina, A.B. Metabolic Plasticity in Developing and Aging Brain. Neurochem. J. 17, 325–337 (2023). https://doi.org/10.1134/S1819712423030157

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