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Features of Changes in Exogenous Heat Shock Proteins (HSP 27 and HSP 70) in Patients with Occupational Nervous System Pathologies

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Abstract—The aim of this study was to identify and compare changes in serum concentrations of heat shock proteins (HSP 27 and HSP 70) in patients with occupational nervous system pathologies induced by exposure to physical and chemical factors. Patients with sensorineural hearing loss (SHL), chronic mercury intoxication (CMI), and vibration disease (VD) formed both under the influence of local vibrations and combined exposure to general and local vibrations were examined. As a result of comparative evaluation and analysis of serum concentrations of heat shock proteins, peculiarities in their changes were revealed. In individuals with SHL and VD due to local vibration exposure, a decrease in the serum HSP 70 concentration was recorded, and, in patients with CMI and VD due to combined local and general vibration exposure, high HSP 27 concentrations were recorded. The examination of patients in the related samples in 3 years showed the absence of statistically significant differences and the preservation of changes in the contents of exogenous HSPs, which confirms the progressive course of these diseases. The association between the number of T-lymphocytes and B-cells with the change in serum HSP concentrations was established, which confirms the roles of HSP 27 and 70 in the regulation of the immune response to VD and allows them to be regarded as markers of cellular and tissue damage in the chronic course of diseases.

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Funding

The work was carried out at the expense of financial resources allocated within the framework of the East-Siberian Institute of Medical and Ecological Research State Assignment.

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  1. East-Siberian Institute of Medical and Ecological Research, Angarsk, Russia

    G. M. Bodienkova & E. V. Boklazhenko

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  1. G. M. Bodienkova
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  2. E. V. Boklazhenko
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Correspondence to G. M. Bodienkova.

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Conflict of interest. The authors declare that they have no conflicts of interest.

Ethical approval. Examination of patients complied with ethical standards in accordance with the Declaration of Helsinki of the World Medical Association (2000) and the Rules of Clinical Practice in the Russian Federation, approved by the Order of the Ministry of Health of the Russian Federation No. 266 dated June 19, 2003.

Informed consent. The studies were performed with the informed consent of the patients and were approved by the Ethics Committee of the All-Russian Scientific Research Center for Health Sciences of the Siberian Branch of the Russian Academy of Medical Sciences (Protocol No. 5 dated November 14, 2012).

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Corresponding author; address: PO box 1170, 12a m-n 3, Irkutsk region, Angarsk, 665827 Russia; e-mail: immun11@yandex.ru.

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Bodienkova, G.M., Boklazhenko, E.V. Features of Changes in Exogenous Heat Shock Proteins (HSP 27 and HSP 70) in Patients with Occupational Nervous System Pathologies. Neurochem. J. 17, 418–422 (2023). https://doi.org/10.1134/S1819712423030054

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  • DOI: https://doi.org/10.1134/S1819712423030054

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