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The Association between Certain Immunological Indices and the Distribution of the Level of the Constant Brain Potential in Neurosensory Hearing Loss

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Abstract—The aim of this study was to identify the relationship between the changes in certain immune system parameters (cytokines and neuronal antibodies) and the distribution of the level of constant brain potential (LCP) in patients with occupational neurosensory hearing loss (NHL). We examined 55 males with occupational NHL formed under the influence of aviation noise and 34 relatively healthy males of comparable ages. As a result of correlation analysis, we found that the higher the concentration is of proinflammatory IL-1β, which is the first to be involved in the body’s reaction by regulating the nonspecific and specific immune response, the higher the LCP of the inter-hemisphere frontal asymmetry of energy metabolism (Fd–Fs) is. In contrast, an increase in TNF-α concentration was accompanied by a decrease in the LCP in the left frontal lead (Fs). These results can indicate the important role of IL-1β and TNF-α in the regulation of interhemispheric activity during hyperpolarization of neuronal membranes in the frontal parts of the brain and activation in the frontal parts of the brain; they also confirm that cytokine regulation of the immune response occurs at the level of entire body. We also showed the deficiency of some relationships and the appearance of new negative relationships between the level of antibodies (AB) to proteins: V-gated Ca-channel, Chol-R, Ser-R, and the LCP in the right and left parietal regions (Pd, Ps), AB to GABA-R, Glu-R, and the LCP in the left parietal region (Ps), ABs to Glu-R with parameters of inter-hemisphere frontal asymmetry of the LCP (Fd–Fs), which indicates an important role of neuroautoimmune reactions in the development of brain energy metabolism disorders. The LCP characteristics that correlate with immunochemical parameters reflect not only neurophysiological mechanisms but also characterize the functional state of the adaptive systems of the body in general. In the future, this can be used in practice to develop new methods for diagnosing various conditions.

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REFERENCES

  1. Tarasova, N.V. and Korzhenkova, A.V., Vestnik Meditsinskogo instituta REAVIZ, 2011, no. 3, pp. 20–26.

  2. Khader, P., Slow brain potentials reveal the neural dynamics of cognitive functions. URL: https//www. mendeley.com/profiles/patrick-khader/ (reference date 04.06.2015)

  3. Fokin, V.F., and Ponomareva, I.V., Energeticheskaya fiziologiya mozga [Energy Physiology of the Brain], Moscow, Antidor, 2003, 288 p.

    Google Scholar 

  4. Deputat, I.S., Nekhoroshkova, A.N., Gribanov, A.V., Bolshevidtseva, I.L., and Startseva, L.F., Ekologiya cheloveka (Human Ecology), 2015, no. 10, pp. 27–36.

  5. Sheshegov, P.M., Zingin, V.N., and Slivina, L.P., Aviakosmicheskaya i Ekologicheskaya Meditsina, 2018, vol. 52, no. 3, pp. 62–68.

    Google Scholar 

  6. Shevchenko, O.I., Rusanova, D.V., Lakhman, O.L., Gig. Sanit., 2018, vol. 98, no. 10, pp. 1068–1073.

    Article  Google Scholar 

  7. Bodienkovaa, G.M., Boklazhenko, E.V., Neurochemical Journal, 2021, vol. 15, no. 1, pp. 91–94.

    Article  Google Scholar 

  8. Sokolova, L.P., International Journal of Experimental Education, 2011, no. 6, p. 29.

  9. Zhang, Q., Adiseshaiah, P., and Reddy, S.P., Am. J. Respir. Cell Mol. Biol., 2005, vol. 32, no. 1, pp. 72–81.

    Article  Google Scholar 

  10. Kassiotis, G., and Kollias, G., J. Exp. Med., 2001, no. 193, pp. 427–434.

  11. Lindbergh, C.A., Casaletto, K.B., Staffaroni, A.M., and Elahi, F., The Journals of Gerontology Series A Biological Sciences and Medical Sciences, 2019, vol. 75(8), pp. 1558–1565.

    Article  Google Scholar 

  12. Sozaeva, D.I., and Berezhanskay, S.B., Kubanskii nauchnyi meditsinskii vestnik, 2014, no. 3 (145), pp. 145–150.

  13. Pankov, M.N., Deputat, I.S., Kozhevnikova, I.S., and Bagretsova, T.V., Scientific Review. Biological science, 2018, no. 5, pp. 5–9. URL: https://science-biology.ru/ru/article/view?id=1116 (reference date: 07.06.2021).

  14. Shevchenko, O.I., and Lakhman, O.L., Ekologiya cheloveka (Human Ecology), 2020, no. 2, pp. 18–23.

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Funding

The study was supported by state assignment to FSBSI ESIMER.

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Authors and Affiliations

  1. East-Siberian Institute of Medical and Ecological Research, Angarsk, Russia

    G. M. Bodienkova, O. L. Lakhman, E. V. Boklazhenko & O. I. Shevchenko

Authors
  1. G. M. Bodienkova
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  2. O. L. Lakhman
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  3. E. V. Boklazhenko
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  4. O. I. Shevchenko
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Corresponding author

Correspondence to G. M. Bodienkova.

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Conflict of interests. The authors declare no conflict of interests.

Ethical approval. The patients were examined in compliance with the World Medical Association’s Declaration of Helsinki (2000) and “Good Clinical Practice in the Russian Federation” approved by the order of the Health Ministry No. 266 of June 19, 2003.

Informed consent. Patients gave their informed consent to participate in the study which was approved by the ESRC HE SB RAMS ethics committee (protocol No. 5 of November 14, 2012).

Additional information

Corresponding author; address: POB 1170, 3, 12a mikrorayon, Angarsk, Irkutsk region, 665827 Russia; phone: +7(3955)58-69-10 (ext. 1411); e-mail: immun11@yandex.ru.

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Bodienkova, G.M., Lakhman, O.L., Boklazhenko, E.V. et al. The Association between Certain Immunological Indices and the Distribution of the Level of the Constant Brain Potential in Neurosensory Hearing Loss. Neurochem. J. 16, 343–348 (2022). https://doi.org/10.1134/S1819712422330017

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  • DOI: https://doi.org/10.1134/S1819712422330017

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