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Neuroprotective Potential of Creatine. Hidden Resources of Its Therapeutic and Preventive Use

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Abstract—The relevant scientific literature has accumulated an extensive array of data indicating the neuroprotective potential of creatine (Cr). However, while many recent experimental and clinical studies confirm the previously revealed neuroprotective therapeutic effects of Cr, the clinical results on certain diseases are uncertain. The primary purpose of this review is, on the one hand, to summarize the experimental data that unequivocally indicate the neuroprotective effectiveness of Cr. On the other hand, this publication seeks to discuss the latest controversies related to some of the clinical trials involving Cr, as well as its prospects for therapeutic and preventive use. As it emerges from the discussion of the presented material, the advantages of Cr as a food supplement are not limited to its use in high-intensity and rehabilitation physical exercises. Remarkably, can have much wider application, both among generally healthy people and various patient groups. Despite somewhat equivocal data from several clinical trials, most researchers are confident that further studies with improved protocols will confirm the neuroprotective therapeutic potential of Cr in neurodegenerative diseases. Already we can state the confirmed efficiency of Cr in Huntington’s disease and traumatic brain damage. There is also promising evidence on the positive therapeutic effect of Cr in the case of such mental disorders as depression, post-traumatic stress disorder, and fibromyalgia. It is obvious that the protective potential of Cr as a natural adaptogen has not yet been fully uncovered; therefore, the spectrum of its areas for therapeutic and preventive application is expected to grow based on the results of the ongoing research activities.

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  1. Institute of Molecular Biology, National Academy of Sciences, Yerevan, Republic of Armenia

    L. S. Nersesova & M. S. Petrosyan

  2. St. Petersburg Institute of Bioregulation and Gerontology, Pr. Dinamo 3, 197022, St. Petersburg, Russia

    A. V. Arutjunyan

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Dedicated to the memory of academician Igor Petrovich Ashmarin

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Nersesova, L.S., Petrosyan, M.S. & Arutjunyan, A.V. Neuroprotective Potential of Creatine. Hidden Resources of Its Therapeutic and Preventive Use. Neurochem. J. 16, 14–30 (2022). https://doi.org/10.1134/S1819712422010093

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