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Intracellular Delivery of an Antibody-Like Molecule Capable of Inhibiting c-Myc

  • BIOCHEMISTRY, BIOPHYSICS, AND MOLECULAR BIOLOGY
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Abstract

A modular nanotransporter (MNT) carrying the sequence of an antibody-like molecule, anti-c-Myc nanobody, was synthesized and characterized. It was demonstrated that the created MNT is able to interact with the target protein, c-Myc oncogene, with a dissociation constant of 46 ± 14 nM, internalize into target cells, change Myc-dependent expression, and exert an antiproliferative effect.

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ACKNOWLEDGMENTS

The experiments were carried out using the equipment of the core facility of the Institute of Gene Biology, Russian Academy of Sciences.

Funding

The study was performed under the development program of Moscow State University with the support of the Russian Science Foundation (project no. 21-14-00130).

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Authors and Affiliations

  1. Institute of Gene Biology, Russian Academy of Sciences, Moscow, Russia

    T. N. Lupanova, A. V. Ulasov, Y. V. Khramtsov, A. A. Rozenkranz,  G. P. Georgiev &  A. S. Sobolev

  2. Moscow State University, Moscow, Russia

    A. A. Rozenkranz &  A. S. Sobolev

Authors
  1. T. N. Lupanova
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  2. A. V. Ulasov
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  3. Y. V. Khramtsov
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  4. A. A. Rozenkranz
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  5. G. P. Georgiev
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  6. A. S. Sobolev
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Corresponding authors

Correspondence to T. N. Lupanova or A. S. Sobolev.

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The authors declare that they have no conflicts of interest. This article does not contain any studies involving animals or human participants performed by any of the authors.

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Translated by M. Batrukova

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Lupanova, T.N., Ulasov, A.V., Khramtsov, Y.V. et al. Intracellular Delivery of an Antibody-Like Molecule Capable of Inhibiting c-Myc. Dokl Biochem Biophys 509, 70–72 (2023). https://doi.org/10.1134/S1607672923700114

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  • DOI: https://doi.org/10.1134/S1607672923700114

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