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A New Technology for Recovery of Locomotion in Patients after a Stroke

  • BIOCHEMISTRY, BIOPHYSICS, AND MOLECULAR BIOLOGY
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Abstract

Neural networks in the spinal cord can generate the walking pattern and control posture in the absence of supraspinal influences. A technology using transcutaneous electrical spinal cord stimulation (tSCS) was created. During walking, tSCS activated spinal locomotor networks, as well as leg flexor/extensor motor pools in the swing/stance phases, respectively. It was assumed that the use of this technology in subjects with locomotion disorders would improve walking. Patients with hemiparesis were studied 3–11 months after stroke, the duration of the course was 2 weeks. Patients of the main and control groups received standard therapy and rehabilitation using the technology; in the control group, sham tSCS was used. After the course, minimal clinically important differences in walking parameters were achieved in the main group, in contrast to the control group. The developed technology is an effective means of restoring walking in patients with hemiparesis.

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ACKNOWLEDGMENTS

The study was performed using the “Spinal Neuroprosthesis” apparatus for neurostimulation in variants according to TU 26.60.13-004-65248030-2021 (Cosyma Ltd).

Funding

The study was supported by the Foundation for Support of National Technical Initiative Projects (contract no. 33/19gr dated November 21, 2019) and the State Basic Research Program (topic no. 0113-2019-0006, 63.4).

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Authors and Affiliations

  1. Pavlov Institute of Physiology, Russian Academy of Sciences, St. Petersburg, Russia

    T. R. Moshonkina, S. S. Ananev, N. D. Shandybina, E. A. Vershinina, V. A. Lyakhovetskii, A. A. Grishin &  Y. P. Gerasimenko

  2. Almazov National Medical Research Centre, St. Petersburg, Russia

    E. N. Zharova &  E. V. Shlyakhto

Authors
  1. T. R. Moshonkina
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  2. E. N. Zharova
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  3. S. S. Ananev
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  4. N. D. Shandybina
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  5. E. A. Vershinina
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  6. V. A. Lyakhovetskii
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  7. A. A. Grishin
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  8. E. V. Shlyakhto
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  9. Y. P. Gerasimenko
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Corresponding author

Correspondence to T. R. Moshonkina.

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Conflict of interest. The authors have no potential and obvious conflicts of interest related to the manuscript.

Statement of compliance with standards of research involving humans as subjects. The clinical trial was approved at a meeting of the Council on Ethics in the Sphere of Circulation of Medical Devices of the Ministry of Health of the Russian Federation (minutes no. 40 dated February 7, 2022). All study participants signed an informed consent.

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Translated by M. Batrukova

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Moshonkina, T., Zharova, E., Ananev, S. et al. A New Technology for Recovery of Locomotion in Patients after a Stroke. Dokl Biochem Biophys 507, 353–356 (2022). https://doi.org/10.1134/S1607672922340087

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  • DOI: https://doi.org/10.1134/S1607672922340087

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