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Sigma-1 Receptor Agonist Amitriptyline Inhibits Store-Dependent Ca2+ Entry in Macrophages

  • BIOCHEMISTRY, BIOPHYSICS, AND MOLECULAR BIOLOGY
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Abstract

Using Fura-2AM microfluorimetry, we have shown for the first time that sigma-1 receptor agonist–tricyclic antidepressant amitriptyline—significantly inhibits store-dependent Ca2+ entry, induced by endoplasmic Ca2+-ATPase inhibitors thapsigargin and cyclopiazonic acid, in rat peritoneal macrophages. The results suggest a possible involvement of sigma-1 receptors in the regulation of store-dependent Ca2+ entry in macrophages.

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Authors and Affiliations

  1. St. Petersburg State University, St. Petersburg, Russia

    Z. I. Krutetskaya, L. S. Milenina, V. G. Antonov &  A. D. Nozdrachev

  2. Institute of Physiology, Russian Academy of Sciences, St. Petersburg, Russia

    A. D. Nozdrachev

Authors
  1. Z. I. Krutetskaya
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  2. L. S. Milenina
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  3. V. G. Antonov
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  4. A. D. Nozdrachev
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Corresponding authors

Correspondence to Z. I. Krutetskaya or A. D. Nozdrachev.

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Conflict of interests. The authors declare that they have no conflict of interest.

Statement on the welfare of animals. All applicable international, national, and/or institutional guidelines for the care and use of animals were followed.

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Translated by M. Batrukova

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Krutetskaya, Z.I., Milenina, L.S., Antonov, V.G. et al. Sigma-1 Receptor Agonist Amitriptyline Inhibits Store-Dependent Ca2+ Entry in Macrophages. Dokl Biochem Biophys 488, 307–310 (2019). https://doi.org/10.1134/S1607672919050041

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  • DOI: https://doi.org/10.1134/S1607672919050041

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