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The Antiproliferative Effect of the “Early” Protein E2 of Papillomavirus HPV16 on Testis Tumors of Mice Induced by the Injection of HeLa Cells

  • BIOCHEMISTRY, BIOPHYSICS, AND MOLECULAR BIOLOGY
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Abstract

The antiproliferative effect of the “early” protein E2 of the high-risk oncogenic human papillomavirus HPV16 on mouse testis tumors, which were induced by the intramuscular injection of HeLa cells, was discovered. The regression of tumors was maximum in the first 2 days after the oral vaccination with HPV16 E2 (500 mg per mouse) and then gradually decreased to the control variant. A typical monolayer of HeLa cells on the cultivation flask bottom, of which only 18% were functionally active, appeared after seeding testis tissue cells on DMEM medium.

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Authors and Affiliations

  1. Siberian Institute of Plant Physiology and Biochemistry, Siberian Branch, Russian Academy of Sciences, 664033, Irkutsk, Russia

    R. K. Salyaev, N. I. Rekoslavskaya & A. S. Stolbikov

  2. Irkutsk Scientific Center, Siberian Branch, Russian Academy of Sciences, 664033, Irkutsk, Russia

    R. K. Salyaev, N. I. Rekoslavskaya & A. S. Stolbikov

Authors
  1. R. K. Salyaev
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  2. N. I. Rekoslavskaya
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  3. A. S. Stolbikov
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Correspondence to R. K. Salyaev.

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Conflict of interests. The authors declare that they have no conflict of interest.

Statement on the welfare of animals. All applicable international, national, and/or institutional guidelines for the care and use of animals were followed.

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Translated by M. Batrukova

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Salyaev, R.K., Rekoslavskaya, N.I. & Stolbikov, A.S. The Antiproliferative Effect of the “Early” Protein E2 of Papillomavirus HPV16 on Testis Tumors of Mice Induced by the Injection of HeLa Cells. Dokl Biochem Biophys 488, 296–299 (2019). https://doi.org/10.1134/S1607672919050028

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  • DOI: https://doi.org/10.1134/S1607672919050028

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