Skip to main content
SpringerLink
Log in

General Sources of Dopamine As a Potential Morphogenic Factor in the Developing Striatum of Rats

  • Biochemistry, Biophysics, and Molecular Biology
  • Published:
Doklady Biochemistry and Biophysics Aims and scope Submit manuscript

Abstract

In the striatum of rats at different stages of development, we determined the content of tyrosine hydroxylase and aromatic L-amino acids decarboxylase using double immunohistochemical labeling and estimated the expression level of their transcripts by real-time PCR. We found that, in different periods of development, there are three sources of dopamine in the striatum of rats: bienzymatic nerve fibers (throughout ontogeny), bienzymatic neurons (appear on day 18 of embryonic development), and monoenzymatic neurons (in adult animals). Dopamine, which is synthesized in the striatal neurons in the prenatal period, may function as a morphogenetic factor.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Ugrumov, M.V., J. Chem. Neuroanat., 2009, vol. 38, pp. 241–256.

    Article  PubMed  CAS  Google Scholar 

  2. Kozina, E.A., Kim, A.R., Kurina, A.Y., and Ugrumov, M.V., Neurobiol. Dis., 2017, vol. 98, pp. 108–121.

    Article  PubMed  CAS  Google Scholar 

  3. Ugrumov, M.V., Melnikova, V.I., Lavrentyeva, A.V., Kudrin, V.S., and Rayevsky, K.S., Neuroscience, 2004, vol. 124, no. 3, pp. 629–635.

    Article  PubMed  CAS  Google Scholar 

  4. Ugrumov, M., Taxi, J., Pronina, T., Kurina, A., Sorokin, A., Sapronova, A., and Calas, A., Neuroscience, 2014, vol. 277, pp. 45–54.

    Article  PubMed  CAS  Google Scholar 

  5. Busceti, C.L., Bucci, D., Molinaro, G., Di Pietro, P., Zangrandi, L., Gradini, R., Moratalla, R., Battaglia, G., Bruno, V., Nicoletti, F., and Fornai, F., PLoS One, 2012, vol. 7, no. 9, p. e44025.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  6. Bupesh, M., Vicario, A., Abellan, A., Desfilis, E., Medina, L., Brain Struct. Funct., 2014, vol. 219, pp. 751–776. doi 10.1007/s00429-013-0533-7

    Article  PubMed  CAS  Google Scholar 

  7. Bookout, A.L., Cummins, C.L., Mangelsdorf, D.J., Pesola, J.M., and Kramer, M.F., Curr. Protoc. Mol. Biol., 2006, pp. 15.8.1–15.8.28. doi 10.1002/0471142727.mb1508s73

    Google Scholar 

  8. Olson, L., Seiger, A., and Fuxe, K., Brain Res., 1972, vol. 44, pp. 283–288.

    Article  PubMed  CAS  Google Scholar 

  9. Antonopoulos, J., Dori, I., Dinopoulos, A., Chiotelli, M., and Parnavela, J.G., Neuroscience, 2002, vol. 110, no. 2, pp. 245–256.

    Article  PubMed  CAS  Google Scholar 

  10. Weihe, E., Depboylu, C., Schutz, B., Schafer, M.K., and Eiden, L.E., Cell Mol. Neurobiol., 2006, vol. 26, pp. 659–678.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  11. Pronina, T.S., Ugryumov, M.V., Kalas, A., Tramju, J., and Makarenko, I.G., Zh. Evol. Biokhim. Fiziol., 2001, vol. 37, no. 5, pp. 556–561.

    CAS  Google Scholar 

  12. Yun, K., Garel, S., Fischman, S., and Rubenstein, J.L.R., J. Comp. Neurol., 2003, vol. 461, pp. 151–165.

    Article  PubMed  CAS  Google Scholar 

  13. Berry, M.D., Juorio, A.V., Li, X-M., and Boulton, A.A., Neurochem. Res., 1996, vol. 21, no. 9, pp. 1075–1087.

    Article  PubMed  CAS  Google Scholar 

  14. Abramova, M.A., Calas, A., and Ugrumov, M., Brain Struct. Funct., 2011, vol. 215, pp. 195–207.

    Article  PubMed  CAS  Google Scholar 

  15. Betarbet, R., Turner, R., Chockkan, V., DeLong, M.R., Allers, K.A., Walters, J., Levey, A.I., and Greenamyre, J.T., J. Neurosci., 1997, vol. 17, pp. 6761–6768.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Koltzov Institute of Developmental Biology, Russian Academy of Sciences, Moscow, 119334, Russia

    A. I. Kurtova, L. K. Dil’mukhametova, E. R. Mingazov & M. V. Ugrumov

Authors
  1. A. I. Kurtova
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. L. K. Dil’mukhametova
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. E. R. Mingazov
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. M. V. Ugrumov
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to A. I. Kurtova.

Additional information

Original Russian Text © A.I. Kurtova, L.K. Dil’mukhametova, E.R. Mingazov, M.V. Ugrumov, 2018, published in Doklady Akademii Nauk, 2018, Vol. 479, No. 6, pp. 703–707.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Kurtova, A.I., Dil’mukhametova, L.K., Mingazov, E.R. et al. General Sources of Dopamine As a Potential Morphogenic Factor in the Developing Striatum of Rats. Dokl Biochem Biophys 479, 123–126 (2018). https://doi.org/10.1134/S1607672918020199

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1134/S1607672918020199

Search

Navigation