Abstract
It is shown that endothelial cells from human umbilical vein have a reduced activity and gene expression of the “classic” antioxidant enzymes (Cu,Zn-superoxide dismutase, catalase, and Se-containing glutathione peroxidase). At the same time, a high expression level of peroxiredoxin genes was identified in the same endothelial cells, which obviously indicates the predominant involvement of these enzymes in protecting the endothelium from the damaging effect of free radical peroxidation.
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Original Russian Text © M.G. Sharapov, R.G. Goncharov, A.E. Gordeeva, V.I. Novoselov, O.A. Antonova, A.K. Tikhaze, V.Z. Lankin, 2016, published in Doklady Akademii Nauk, 2016, Vol. 471, No. 2, pp. 241–244.
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Sharapov, M.G., Goncharov, R.G., Gordeeva, A.E. et al. Enzymatic antioxidant system of endotheliocytes. Dokl Biochem Biophys 471, 410–412 (2016). https://doi.org/10.1134/S1607672916060090
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DOI: https://doi.org/10.1134/S1607672916060090