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SV40 transcription terminators stabilize the activity of regulatory elements in Drosophila melanogaster

  • Biochemistry, Biophysics and Molecular Biology
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Abstract

To ensure stable operation of transgenic systems and maintain reporter gene expression at a certain level, it is necessary to search for the conditions that protect the activity of regulatory elements. In this study, we have shown that the SV40 transcription terminators flanking the transgene protect enhancers and silencers of Drosophila and ensure their efficient functioning.

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Authors and Affiliations

  1. Institute of Gene Biology, Russian Academy of Sciences, ul. Vavilova 34/5, Moscow, 119334, Russia

    D. A. Chetverina, P. V. Elizar’ev, P. G. Georgiev & M. M. Erokhin

Authors
  1. D. A. Chetverina
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  2. P. V. Elizar’ev
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  3. P. G. Georgiev
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  4. M. M. Erokhin
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Corresponding author

Correspondence to D. A. Chetverina.

Additional information

Original Russian Text © D.A. Chetverina, P.V. Elizar’ev, P.G. Georgiev, M.M. Erokhin, 2015, published in Doklady Akademii Nauk, 2015, Vol. 463, No. 5, pp. 611–614.

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Chetverina, D.A., Elizar’ev, P.V., Georgiev, P.G. et al. SV40 transcription terminators stabilize the activity of regulatory elements in Drosophila melanogaster . Dokl Biochem Biophys 463, 251–254 (2015). https://doi.org/10.1134/S1607672915040134

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  • DOI: https://doi.org/10.1134/S1607672915040134

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