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Synthesis of Phenylboronic Acid-Based Microgels and Their Glucose-Responsive Properties

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Abstract

In this article, glucose-responsive polymers were synthesized by introducing hydrophilic monomer N-vinyl-2-pyrrolidone and amino-containing monomer N,N-dimethylaminopropyl acrylamide to make phenylboronic acid-based polymers able to response in physiological temperature and physiological pH. The chemical structure of the polymer was confirmed by NMR spectroscopy. The aqueous solutions of polymer were characterized by lower critical solution temperature, which increased with rise of glucose concentration. Further, the glucose-sensitive microgels were prepared by reversed-phase microemulsion method. The results showed that the microgels could response at physiological environment and the particle size of microgels increased with increasing glucose concentration.

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Funding

Financial supports from the Science and Technology Program of Zhejiang Province (2019C03063), the Natural Science Foundation of Zhejiang Province (LY19B040007) are gratefully acknowledged.

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Authors and Affiliations

  1. State Key Laboratory of Chemical Engineering, College of Chemical and Biological Engineering, Zhejiang University, 310027, Hangzhou, China

    Nan Wang, Haojie Yu, Li Wang, Xiang Chen, Ruixue Liang & Yusheng Xing

  2. Oncological Surgery and Cancer Center, the First Affiliated Hospital, Zhejiang University, 310003, Hangzhou, China

    Lisong Teng

Authors
  1. Nan Wang
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  2. Haojie Yu
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  3. Li Wang
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  4. Xiang Chen
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  5. Ruixue Liang
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  7. Lisong Teng
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Correspondence to Haojie Yu.

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Nan Wang, Yu, H., Wang, L. et al. Synthesis of Phenylboronic Acid-Based Microgels and Their Glucose-Responsive Properties. Polym. Sci. Ser. B 63, 521–530 (2021). https://doi.org/10.1134/S1560090421050171

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  • DOI: https://doi.org/10.1134/S1560090421050171

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