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Synthesis and Antimicrobial Activity of New Methyl Pyrazolo[5,1-c][1,2,4]benzotriazine-2-carboxylate Derivatives

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Abstract

New methyl pyrazolo[5,1-c][1,2,4]benzotriazine-2-carboxylate derivatives have been synthesized under mild conditions in two steps (reductive cyclization followed by diazotation) from hydrazones obtained by condensation of dimethyl acetylenedicarboxylate and 2-nitrophenylhydrazine derivatives. The synthesized compounds exhibited moderate to good antimicrobial activity against five bacterial strains (Escherichia coli, Staphylococcus aureus, Staphylococcus epidermidis, Bacillus subtilis, and Pseudomonas aeruginosa) and two fungal strains (Saccharomyces cerevisiae and Candida albicans).

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ACKNOWLEDGMENTS

The authors are grateful to the Institute of Analytical Chemistry, University of Leipzig (Germany) for measuring the NMR and mass spectra. We also express our gratitude to Prof. H. Boutoumi for his human and scientific skills.

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Authors and Affiliations

  1. Laboratoire Matériaux et Environnement (LME), Faculté de Technologie, Université Yahia Farès de Médéa, 26000, Medea, Algeria

    H. Lettreuch

  2. Faculté de Technologie, Université de Blida 1, 09000, Blida, Algeria

    M. Khodja

  3. Laboratoire Chimie-Physique Moléculaire et Macromoléculaire, Université de Blida 1, 09000, Blida, Algeria

    S. Moulay

  4. Laboratoire de Génie Chimique (LGC), Faculté de Technologie, Université de Blida 1, 09000, Blida, Algeria

    A. Drioueche

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  1. H. Lettreuch
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  2. M. Khodja
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  4. A. Drioueche
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Correspondence to H. Lettreuch.

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Lettreuch, H., Khodja, M., Moulay, S. et al. Synthesis and Antimicrobial Activity of New Methyl Pyrazolo[5,1-c][1,2,4]benzotriazine-2-carboxylate Derivatives. Russ J Org Chem 59, 674–678 (2023). https://doi.org/10.1134/S1070428023040164

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