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Synthesis of New 1-Hydroxy-4H-pyrrolo[3,2,1-ij]quinolin-2(1H)-one Derivatives

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Abstract

Aldol addition of acyclic and cyclic ketones to 4,4,6-trimethyl-4H-pyrrolo[3,2,1-ij]quinoline-1,2-diones afforded the corresponding 1-substituted 1-hydroxy-4,4,6-trimethyl-4H-pyrrolo[3,2,1-ij]quinolin-2(1H)-ones. The short-time reduction of 4,4,6-trimethyl-4H-pyrrolo[3,2,1-ij]quinoline-1,2-diones with sodium tetra­hydridoborate gave 1-hydroxy-4,4,6-trimethyl-4H-pyrrolo[3,2,1-ij]quinolin-2(1H)-ones.

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ACKNOWLEDGMENTS

The IR and mass spectra were recorded using the research facilities of the joint scientific equipment center at the Voronezh State University.

Funding

This study was performed under financial support by the Russian Science Foundation (project no. 18-74-10097-P).

Author information

Authors and Affiliations

  1. Voronezh State University, 394018, Voronezh, Russia

    N. P. Novichikhina, A. S. Shestakov, A. A. Skoptsova, Z. E. Ashrafova, N. V. Stolpovskaya, E. A. Kosheleva, G. V. Shatalov, I. V. Ledenyova & Kh. S. Shikhaliev

Authors
  1. N. P. Novichikhina
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  2. A. S. Shestakov
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  3. A. A. Skoptsova
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  4. Z. E. Ashrafova
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  5. N. V. Stolpovskaya
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  6. E. A. Kosheleva
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  7. G. V. Shatalov
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  8. I. V. Ledenyova
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  9. Kh. S. Shikhaliev
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Correspondence to Kh. S. Shikhaliev.

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The authors declare the absence of conflict of interest.

Additional information

Translated from Zhurnal Organicheskoi Khimii, 2021, Vol. 57, No. 10, pp. 1393–1402 https://doi.org/10.31857/S0514749221100049.

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Novichikhina, N.P., Shestakov, A.S., Skoptsova, A.A. et al. Synthesis of New 1-Hydroxy-4H-pyrrolo[3,2,1-ij]quinolin-2(1H)-one Derivatives. Russ J Org Chem 57, 1592–1599 (2021). https://doi.org/10.1134/S1070428021100043

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