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Synthesis and Biological Activity of Partially Hydrogenated 1-Aminopyrimido[4,5-c]isoquinoline Derivatives

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Abstract

A one-pot synthesis of 3-amino-2-aryl-1,2,5,6,7,8-hexahydroisoquinolin-1-ones by the nucleophilic substitution at position 1 of the pyridine ring was developed. The synthesized compounds were used to prepare 1-amino-7,8,9,10-tetrahydropyrimido[4,5-c]isoquinoline derivatives. The biological properties of the products were studied.

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REFERENCES

  1. Mashkovskii, M.D., Lekarstvennye sredstva (Drugs), Moscow: Novaya Volna, 2010.

  2. Shimazaki, T. and Kondo, H., JP Patent no. 7916096, 1980; Chem. Abstr., 1980, vol. 93, no. 46709m.

  3. Reddy, M.V.R., Akula, B., Cosenza, S.C., Athuluridivakar, S., Mallireddigari, M.R., Pallela, V.R., Billa, V.K., Subbaiah, D.R.C.V., Bharathi, E.V., Carpio, R.V., Padgaonkar, A., Baker, S.J., and Reddy, E.P., J. Med. Chem., 2014, vol. 57, p. 578. https://doi.org/10.1021/jm401073p

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Vásquez, D., Rodríguez, J.A., Theoduloz, C., Verrax, J., Calderon, P.B., and Valderrama, J.A., Bioorg. Med. Chem. Lett., 2009, vol. 19, p. 5060. https://doi.org/10.1016/j.bmcl.2009.07.041

    Article  CAS  PubMed  Google Scholar 

  5. Paronikyan, E.G., Dashyan, Sh.Sh., Noravyan, A.S., Tamazyan, R.A., Ayvazyan, A.G., and Panosyan, H.A., Tetrahedron, 2015, vol. 71, p. 2686. https://doi.org/10.1016/j.tet.2015.03.040

    Article  CAS  Google Scholar 

  6. Rukovodstvo po provedeniyu doklinicheskikh issledovanii lekarstvennykh sredstv (A Guide to Preclinical Trials of Medicines), Mironov, A.N., Ed., Moscow: Meditsina, 2012, vol. 1.

  7. Sof’ina, Z.P., Syrkin, A.V., Goldin, A., and Klyain, A., Eksperimental’naya otsenka protivoopukholevykh preparatov v SSSR i SShA (Experimental Assessment of Antitumor Drugs in the USSR and USA), Moscow: Meditsina, 1980.

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Authors and Affiliations

  1. Scientific and Technological Center of Organic and Pharmaceutical Chemistry, National Academy of Science of Armenia, 0014, Yerevan, Armenia

    E. G. Paronikyan, Sh. Sh. Dashyan & H. M. Stepanyan

Authors
  1. E. G. Paronikyan
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  2. Sh. Sh. Dashyan
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  3. H. M. Stepanyan
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Correspondence to Sh. Sh. Dashyan.

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Paronikyan, E.G., Dashyan, S.S. & Stepanyan, H.M. Synthesis and Biological Activity of Partially Hydrogenated 1-Aminopyrimido[4,5-c]isoquinoline Derivatives. Russ J Org Chem 56, 1963–1968 (2020). https://doi.org/10.1134/S1070428020110111

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  • DOI: https://doi.org/10.1134/S1070428020110111

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