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Synthesis of 2-(1,3-Diphenyl-1H-1,2,4-triazol-5-yl)-2,2-dinitroacetonitrile and Its Reaction with Diazomethane

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Abstract

A method for the synthesis of 2-(1,3-diphenyl-1H-1,2,4-triazol-5-yl)-2,2-dinitroacetonitrile was developed, and its reaction with diazomethane was investigated to show the reaction involves 1,3-dipolar cycloaddition and forms a separable mixture of 4-[(1,3-diphenyl-1H-1,2,4-triazol-5-yl)dinitromethyl]-2H-1,2,3-triazoles. The latter react with KOH in ethanol to form potassium salts of 4-[(1,3-diphenyl-1H-1,2,4-triazole-5-yl)aci-nitromethyl]-1,2,3-triazoles.

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Authors and Affiliations

  1. Astrakhan State University, 414000, Astrakhan, Russia

    A. G. Tyrkov

  2. Vologograd State Medical University, Branch of Pyatigorsk Medical and Pharmaceutical Institute, 357532, Pyatigorsk, Russia

    E. A. Yurtaeva

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  1. A. G. Tyrkov
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  2. E. A. Yurtaeva
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Correspondence to A. G. Tyrkov.

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Tyrkov, A.G., Yurtaeva, E.A. Synthesis of 2-(1,3-Diphenyl-1H-1,2,4-triazol-5-yl)-2,2-dinitroacetonitrile and Its Reaction with Diazomethane. Russ J Org Chem 56, 1407–1411 (2020). https://doi.org/10.1134/S1070428020080114

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  • DOI: https://doi.org/10.1134/S1070428020080114

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