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Synthesis and Antioxidant Activity of Ethyl 2-Amino-6-cyano-6-phenyl-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylates and 3-Amino-4-oxo-7-phenyl-3,4,5,6,7,8-hexahydrobenzo[4,5]thieno[2,3-d]pyrimidine-7-carbonitriles

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Abstract

Gewald reaction of 4-oxo-1-phenylcyclohexane-1-carbonitrile with ethyl cyanoacetate and elemental sulfur in the presence of diethylamine afforded ethyl 2-amino-6-cyano-6-phenyl-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate which was treated with a series of acid chlorides to obtain the corresponding 2-amido derivatives. Condensation of the latter with hydrazine hydrate gave new fused benzothienopyrimidines. The synthesized compounds were screened for antioxidant activity.

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Authors and Affiliations

  1. Scientific Technological Center of Organic and Pharmaceutical Chemistry, National Academy of Sciences of Armenia, 0014, Yerevan, Armenia

    A. A. Aghekyan, G. G. Mkryan, H. A. Panosyan, G. M. Buniatyan & R. E. Muradyan

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  1. A. A. Aghekyan
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  2. G. G. Mkryan
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  3. H. A. Panosyan
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  4. G. M. Buniatyan
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  5. R. E. Muradyan
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Correspondence to A. A. Aghekyan.

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Aghekyan, A.A., Mkryan, G.G., Panosyan, H.A. et al. Synthesis and Antioxidant Activity of Ethyl 2-Amino-6-cyano-6-phenyl-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylates and 3-Amino-4-oxo-7-phenyl-3,4,5,6,7,8-hexahydrobenzo[4,5]thieno[2,3-d]pyrimidine-7-carbonitriles. Russ J Org Chem 56, 440–445 (2020). https://doi.org/10.1134/S1070428020030124

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  • DOI: https://doi.org/10.1134/S1070428020030124

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