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A Simple Efficient Click Synthesis of Novel Crown Ethers Containing 1,2,3-Triazole Moieties

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Abstract

Novel crown ether derivative containing 1,4-disubstituted-1,2,3-triazole moieties were synthesized. At the first step of the synthesis 4,13-diaza-18-crown-6 and 4-aminobenzo-15-crown-5 were converted into terminal alkynes, which were then subjected to copper(I)-catalyzed alkyne-azide coupling (CuAAC) in methylene chloride. This coupling reaction was performed according to the concept of click chemistry, using an Amberlyst A-21-supported copper(I) iodide catalyst.

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Authors and Affiliations

  1. Unit of Chemical and Biological Technologies for Health, UMR 8258 CNRS/U1022 Inserm, National Chemical Engineering Institute in Paris, Chimie Paristech - PSL Research University, 11 rue Pierre et Marie Curie, Paris, 75005, France

    H. Elamari & C. Girard

  2. Unit of Functional Physiology and Valorization ofBioresources (UR17ES27), Higher Institute of Biotechnology of Beja, University of Jendouba, Beja, 9000, Tunisia

    A. Ouerghui

  3. Laboratory of Organic Chemistry and Applications (Unit 05/UR/12-05), Faculty of Sciences of Bizerte, University of Carthage, Bizerte, 7021, Tunisia

    A. Ouerghui & F. Ammari

Authors
  1. H. Elamari
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  2. A. Ouerghui
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  3. F. Ammari
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  4. C. Girard
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Correspondence to A. Ouerghui.

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Elamari, H., Ouerghui, A., Ammari, F. et al. A Simple Efficient Click Synthesis of Novel Crown Ethers Containing 1,2,3-Triazole Moieties. Russ J Org Chem 55, 1785–1790 (2019). https://doi.org/10.1134/S1070428019110228

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  • DOI: https://doi.org/10.1134/S1070428019110228

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