Abstract
A novel and highly efficient synthetic approach has been developed for the synthesis of deuterium-labeled olopatadine-d6 using inexpensive and commercially available dimethyl sulfate-d6 at the stage of alkylation of primary amine intermediate. The proposed synthetic path makes it possible to avoid the use of expensive labeled reagents such as dimethyl amine-d6 used as labeled precursor in the traditional synthetic route. The structure of the obtained olapatadine-d6 has been confirmed by 1H NMR and mass spectral data.
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The authors thank the management of AMRI Hyderabad Research Center for giving an opportunity to carry out this research.
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Endoori, S., Gulipalli, K.C., Bodige, S. et al. Novel and Efficient Synthesis of Deuterium-Labeled Olopatadine-d6. Russ J Org Chem 55, 1387–1393 (2019). https://doi.org/10.1134/S1070428019090197
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DOI: https://doi.org/10.1134/S1070428019090197