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Three-component heterocyclization of 5-(arylmethylidene)pyrimidine-2,4,6(1H,3H,5H)-triones with aldehydes and amino acids

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Abstract

Previously unknown substituted 4-aryl-2,7,9-triazaspiro[4.5]decane-6,8,10-triones were synthesized in 50–70% yield by heating 5-(arylmethylidene)barbituric acids with N-methyl- or N-phenylglycine and para-formaldehyde or 4-methoxybenzaldehyde in boiling toluene for 14 h.

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Authors and Affiliations

  1. Astrakhan State University, pl. Shaumyana 1, Astrakhan, 414000, Russia

    A. G. Tyrkov, E. A. Yurtaeva & L. A. Dan’kova

Authors
  1. A. G. Tyrkov
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  2. E. A. Yurtaeva
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  3. L. A. Dan’kova
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Corresponding author

Correspondence to A. G. Tyrkov.

Additional information

Original Russian Text © A.G. Tyrkov, E.A. Yurtaeva, L.A. Dan’kova, 2017, published in Zhurnal Organicheskoi Khimii, 2017, Vol. 53, No. 7, pp. 1058–1061.

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Tyrkov, A.G., Yurtaeva, E.A. & Dan’kova, L.A. Three-component heterocyclization of 5-(arylmethylidene)pyrimidine-2,4,6(1H,3H,5H)-triones with aldehydes and amino acids. Russ J Org Chem 53, 1071–1074 (2017). https://doi.org/10.1134/S1070428017070181

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  • DOI: https://doi.org/10.1134/S1070428017070181

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