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Synthesis of spiro[imidazole-2,2′-pyrroles] by reaction of 4,5-dioxo-4,5-dihydro-1H-pyrrole-2-carboxylates with urea

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Abstract

Substituted alkyl 4,5-dioxo-4,5-dihydro-1H-pyrrole-2-carboxylates reacted with urea to give alkyl 2-(carbamoylamino)-4-hydroxy-5-oxo-2,5-dihydro-1H-pyrrole-2-carboxylates which underwent intramolecular cyclization to 8-hydroxy-1,3,6-triazaspiro[4.4]non-8-ene-2,4,7-triones by the action of sodium methoxide.

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Authors and Affiliations

  1. Perm State National Research University, ul. Bukireva 15, Perm, 614990, Russia

    A. Yu. Dubovtsev, P. S. Silaichev, M. A. Zheleznova & A. N. Maslivets

  2. Institute of Chemical Physics Problems, Russian Academy of Sciences, Chernogolovka, Moscow oblast, Russia

    Z. G. Aliev

Authors
  1. A. Yu. Dubovtsev
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  2. P. S. Silaichev
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  3. M. A. Zheleznova
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  4. Z. G. Aliev
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  5. A. N. Maslivets
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Corresponding author

Correspondence to A. N. Maslivets.

Additional information

Original Russian Text © A.Yu. Dubovtsev, P.S. Silaichev, M.A. Zheleznova, Z.G. Aliev, A.N. Maslivets, 2016, published in Zhurnal Organicheskoi Khimii, 2016, Vol. 52, No. 12, pp. 1788–1792.

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Dubovtsev, A.Y., Silaichev, P.S., Zheleznova, M.A. et al. Synthesis of spiro[imidazole-2,2′-pyrroles] by reaction of 4,5-dioxo-4,5-dihydro-1H-pyrrole-2-carboxylates with urea. Russ J Org Chem 52, 1779–1783 (2016). https://doi.org/10.1134/S1070428016120113

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  • DOI: https://doi.org/10.1134/S1070428016120113

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