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Alternative synthesis of thiazole-substituted fragment C10-C21 of epothilone D analog

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Abstract

New procedure was developed for preparation of the fragment C10-C21 of epothilone D analog from R-(-)-carvone. The key stage of the synthesis consists in the regio- and stereoselective Wittig reaction of (5R)-5-acetyl-2-methylcyclohex-2-en-1-one with an ylide generated from tributyl[(2-methylthiazol-4-yl)methyl]-phosphonium chloride.

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Authors and Affiliations

  1. Ufa Institute of Chemistry, Russian Academy of Sciences, pr. Oktyabrya 71, Ufa, 450054, Russia

    R. F. Valeev, R. F. Bikzhanov & M. S. Miftakhov

Authors
  1. R. F. Valeev
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  2. R. F. Bikzhanov
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  3. M. S. Miftakhov
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Corresponding author

Correspondence to R. F. Bikzhanov.

Additional information

Original Russian Text © R.F. Valeev, R.F. Bikzhanov, M.S. Miftakhov, 2015, published in Zhurnal Organicheskoi Khimii, 2015, Vol. 51, No. 5, pp. 679–682.

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Valeev, R.F., Bikzhanov, R.F. & Miftakhov, M.S. Alternative synthesis of thiazole-substituted fragment C10-C21 of epothilone D analog. Russ J Org Chem 51, 660–663 (2015). https://doi.org/10.1134/S1070428015050139

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  • DOI: https://doi.org/10.1134/S1070428015050139

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