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3-allylation of tert-butyl 4-oxopiperidine-1-carboxylate

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Abstract

Reaction of tert-butyl 4-oxopiperidine-1-carboxylate dimethylhydrazone with BuLi in the presence of N,N’-dimethylpropylene urea and subsequently with BrCH2CH=CRR’ (R=H, Me, Et; R’=CH2Ar) afforded in 50–80% yields the corresponding tert-butyl 3-alkenyl-4-oxopiperidine-1-carboxylates, promising synthons for preparation of diverse piperidine derivatives.

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Authors and Affiliations

  1. Lipetsk State Pedagogical University, ul. Lenina 42, Lipetsk, 398020, Russia

    A. I. Moskalenko

  2. Timiryazev State Agricultural University, Moscow, Russia

    V. I. Boev

Authors
  1. A. I. Moskalenko
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  2. V. I. Boev
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Correspondence to A. I. Moskalenko.

Additional information

Original Russian Text © A.I. Moskalenko, V.I. Boev, 2014, published in Zhurnal Organicheskoi Khimii, 2014, Vol. 50, No. 11, pp. 1599–1603.

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Moskalenko, A.I., Boev, V.I. 3-allylation of tert-butyl 4-oxopiperidine-1-carboxylate. Russ J Org Chem 50, 1584–1589 (2014). https://doi.org/10.1134/S1070428014110086

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  • DOI: https://doi.org/10.1134/S1070428014110086

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