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Synthesis of Immunoactive Tris(2-hydroxyethyl)ammonium 1-R-Indol-3-ylsulfanyl(sulfonyl)acetates

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Abstract

Difficultly accessible 1-R-indol-3-ylsulfanyl(sulfonyl)acetic acids 1-R-IndYCH2CO2H (R = H, Me, Bn; Y = S, SO2) 1a–Id were prepared. Their reaction with tris(2-hydroxyethyl)amine yielded tris(2-hydroxyethyl) ammonium 1-R-indol-3-ylsulfanyl(sulfonyl)aceetates (protatranes) 2a–2d. The immunoactive properties of 2a–2d were studied. Protatranes 2a, 2c, and 2d proved to be effective immunosuppressive agents (up to 99.5% inhibition of mice splenocyte proliferation in vitro).

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Authors and Affiliations

  1. Favorsky Institute of Chemistry, Siberian Branch, Russian Academy of Sciences, ul. Favorskogo 1, Irkutsk, 664033, Russia

    S. N. Adamovich & A. N. Mirskova

  2. Irkutsk Scientific Center, Siberian Branch, Russian Academy of Sciences, ul. Lermontova 134, Irkutsk, 664033, Russia

    S. N. Adamovich & A. N. Mirskova

Authors
  1. S. N. Adamovich
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  2. A. N. Mirskova
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Corresponding author

Correspondence to A. N. Mirskova.

Additional information

Original Russian Text © S.N. Adamovich, A.N. Mirskova, 2018, published in Zhurnal Prikladnoi Khimii, 2018, Vol. 91, No. 3, pp. 432−435.

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Adamovich, S.N., Mirskova, A.N. Synthesis of Immunoactive Tris(2-hydroxyethyl)ammonium 1-R-Indol-3-ylsulfanyl(sulfonyl)acetates. Russ J Appl Chem 91, 469–472 (2018). https://doi.org/10.1134/S1070427218030205

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  • DOI: https://doi.org/10.1134/S1070427218030205

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