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Novel Terpyridine Conjugated Nitrogen Mustard Derivatives: Synthesis, Spectral Properties, and Anticancer Activity

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Abstract

A series of 2,2′:6′,2′-terpyridine conjugated nitrogen mustard derivatives with structurally symmetrical character and rather small molecular size have been synthesized by a two-step process, and characterized by 1H and 13C NMR, and mass spectra. Photophysical properties of these compounds have been characterized by UV-Vis and fluorescence spectroscopy. The synthesized compounds exhibit high antitumor activity against MDA-MB-231, Siha, 786-O, and A549 cell lines. The most potent compound 1a significantly retards the crawling ability and migration capability of A549 cells and inhibits cells proliferation by inducing cell cycle arrest in G1 phase.

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Funding

This research was funded by the GuangDong Basic and Applied Basic Research Foundation (2019A1515110313), Science and Technology Plan Project of Zhanjiang City (2019A01012, 2021A05045), Program for Scientific Research Start-up Funds of Guangdong Ocean University (R19057), College Students Innovation and Entrepreneurship Training Program of Guangdong Ocean University (CXXL2020291), Guangdong Ocean University Innovation Program (230419100) and Nanhai Youth Scholar Project of Guangdong Ocean University (QNXZ201909).

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Authors and Affiliations

  1. College of Chemistry and Environment, Guangdong Ocean University, 524088, Zhanjiang, China

    Yuanwei Liang, Weiting Huang, Qianyi Situ, Wenhua Qiu, Shixiao Li & Luxin He

  2. College of Food Science and Technology, Guangdong Ocean University, 524088, Zhanjiang, China

    Weiming Su & Jianping Chen

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  1. Yuanwei Liang
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  2. Weiting Huang
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  3. Qianyi Situ
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Correspondence to Jianping Chen.

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Liang, Y., Huang, W., Situ, Q. et al. Novel Terpyridine Conjugated Nitrogen Mustard Derivatives: Synthesis, Spectral Properties, and Anticancer Activity. Russ J Gen Chem 92, 725–731 (2022). https://doi.org/10.1134/S1070363222040144

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