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Synthesis, Structure, and Biological Activity of N-p-(Dimethylamino)-N′-(p-dimethylaminobenzylidene)-N,N′′-diphenylbenzohydrazonohydrazide

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Abstract

A three-component reaction of 3,5-diacetyl-2,6-dimethylpyridine, p-N-dimethylaminobenzaldehyde and phenylhydrazine in the presence of KOH in ethanol gave the condensation product of two p-N-dimethylaminobenzaldehyde and phenylhydrazine molecules, namely bis(biarylhydrazone). Structure of the obtained derivative was proved by the 1H and 13C NMR spectroscopy and X-ray diffraction analysis data. It was shown that the bis(biarylhydrazone) derivative has high antiradical and cytoprotective activity.

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ACKNOWLEDGMENTS

Spectrophotometric studies were carried out using the equipment of the Center for Collective Use “Rational Nature Management and Physical and Chemical Research” of the Tyumen State University.

Funding

The work was supported financially by the Science Committee of the Ministry of Education and Science of the Republic of Kazakhstan (grant “Determination of the cytoprotective potential of pharmacologically active compounds with previously established high antioxidant activity”, IRN AP09562310).

Author information

Authors and Affiliations

  1. Tyumen State University, 625003, Tyumen, Russia

    A. L. Stalinskaya & I. V. Kulakov

  2. Republican State Enterprise ”National Center for Biotechnology” of the Science Committee of the Ministry of Education and Science of the Republic of Kazakhstan, 010000, Nur-Sultan, Kazakhstan

    Z. T. Shulgau, Sh. D. Sergazy & A. E. Gulyaev

  3. Karaganda Technical University, 100010, Karaganda, Kazakhstan

    D. M. Turdybekov

  4. E.A. Buketov Karaganda University, 100024, Karaganda, Kazakhstan

    K. M. Turdybekov

Authors
  1. A. L. Stalinskaya
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  2. Z. T. Shulgau
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  3. Sh. D. Sergazy
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  4. A. E. Gulyaev
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  5. D. M. Turdybekov
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  6. K. M. Turdybekov
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  7. I. V. Kulakov
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Correspondence to Sh. D. Sergazy.

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Stalinskaya, A.L., Shulgau, Z.T., Sergazy, S.D. et al. Synthesis, Structure, and Biological Activity of N-p-(Dimethylamino)-N′-(p-dimethylaminobenzylidene)-N,N′′-diphenylbenzohydrazonohydrazide. Russ J Gen Chem 92, 147–153 (2022). https://doi.org/10.1134/S1070363222020025

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