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Development of New Molecular Entities as Potent Antifungal Agents: Synthesis of Substituted 1,2,3-Triazoles

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Abstract

A series of novel 1,2,3-triazoles (8a–8m) were synthesized using click chemistry in excellent yields and were characterized by IR, NMR, MASS spectroscopy and elemental analysis. The final compounds 8a–8m were assessed for their antifungal activity. Among the compounds tested 8h, 8i, 8b, and 8e demonstrated potent antifungal activity where as compounds 8j, 8d, 8l, and 8f were exhibited good antifungal activity against tested fungal strains compared to the reference drug Nystatin.

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REFERENCES

  1. Xu, Z., Eur. J. Med. Chem., 2020, p. 112686. https://doi.org/10.1016/j.ejmech.2020.112686

  2. de Oliveira, V.N.M., do Amaral Moura, C.F., dos Santos Peixoto, A., Ferreira, V.P.G., Araújo, H.M., Pimentel, L.M.L.M., do Ó Pessoa, C., Nicolete, R., Dos Anjos, J.V., and Sharma, P.P., Eur. J. Med. Chem., 2021, vol. 220, p. 113472. https://doi.org/10.1016/j.ejmech.2021.113472

    Article  CAS  Google Scholar 

  3. Kumar, A.K., Sunitha, V., Shankar, B., Krishna, T.M., Lincoln, C.A., and Jalapathi, P., Russ. J. Gen. Chem., 2017, vol. 87, p. 2011. https://doi.org/10.1134/S1070363217090171

    Article  Google Scholar 

  4. Kumar, A.K., Sunitha, V., Ramesh, G., and Jalapathi, P., Russ. J. Gen. Chem., 2020, vol. 90, no. 12, p. 2386. https://doi.org/10.1134/S1070363220120257

    Article  CAS  Google Scholar 

  5. Sunitha, V., Kishore Kumar, A., Shankar, B., Anil Kumar, A., Krishna, T.M., Lincoln, C.A., and Pochampalli, J., Russ. J. Gen. Chem., 2017, vol. 87, p. 322. https://doi.org/10.1134/S1070363217020281

    Article  CAS  Google Scholar 

  6. Himo, F., Lovell, T., Hilgraf, R., Rostovtsev, V.V., Noodleman, L., Sharpless, K.B., and Fokin, V.V., J. Am. Chem. Soc., 2005, vol. 127, no. 1, p. 210. https://doi.org/10.1021/ja0471525

    Article  CAS  PubMed  Google Scholar 

  7. Aher, N.G., Pore, V.S., Mishra, N.N., Kumar, A., Shukla, P.K., Sharma, A., and Bhat, M.K., Bioorg. Med. Chem. Lett., 2009, vol. 19, no. 3, p. 759. https://doi.org/10.1016/j.bmcl.2008.12.026

    Article  CAS  PubMed  Google Scholar 

  8. Bitla, S., Gayatri, A.A., Puchakayala, M.R., Kumar Bhukya, V., Vannada, J., Dhanavath, R., Kuthati, B., Kothula, D., Sagurthi, S.R., and Atcha, K.R., Bioorg. Med. Chem. Lett., 2021, vol. 41, p. 128004. https://doi.org/10.1016/j.bmcl.2021.128004

    Article  CAS  PubMed  Google Scholar 

  9. Demaray, J.A., Thuener, J.E., Dawson, M.N., and Sucheck, S.J., Bioorg. Med. Chem. Lett., 2008, vol. 18, no. 17, p. 4868. https://doi.org/10.1016/j.bmcl.2008.07.087

    Article  CAS  PubMed  Google Scholar 

  10. Wang, X.-L., Wan, K., and Zhou, C.-H., Eur. J. Med. Chem., 2010, vol. 45, no. 10, p. 4631. https://doi.org/10.1016/j.ejmech.2010.07.031

    Article  CAS  PubMed  Google Scholar 

  11. Kumar, A.K., Sunitha, V., Shankaraiah, P., Siddhartha, M., and Jalapathi, P., Russ. J. Gen. Chem., 2018, vol. 88, p. 789. https://doi.org/10.1134/S1070363218040254

    Article  Google Scholar 

  12. Sunitha, V., Kumar, A. K., Shankaraiah, P., Jalapathi, P., and Lincoln, C.A., Russ. J. Gen. Chem., 2018, vol. 88, p. 1515. https://doi.org/10.1134/S1070363218070265

    Article  CAS  Google Scholar 

  13. Sunitha, V., Kumar, A.K., Jalapathi, P., and Lincoln, C.A., Russ. J. Gen. Chem., 2020, vol. 90, p. 154. https://doi.org/10.1134/S1070363220010247

    Article  CAS  Google Scholar 

  14. Kamal, A., Shankaraiah, N., Devaiah, V., Reddy, K.L., Juvekar, A., Sen, S., Kurian, N., and Zingde, S., Bioorg. Med. Chem. Lett., 2008, vol. 18, no. 4, p. 1468. https://doi.org/10.1016/j.bmcl.2007.12.063

    Article  CAS  PubMed  Google Scholar 

  15. Yan, S.-J., Liu, Y.-J., Chen, Y.-L., Liu, L., and Lin, J., Bioorg. Med. Chem. Lett., 2010, vol. 20, no. 17, p. 5225. https://doi.org/10.1016/j.bmcl.2010.06.141

    Article  CAS  Google Scholar 

  16. Kishore Kumar, A., Sunitha, V., Shankar, B., Ramesh, M., Murali Krishna, T., and Jalapathi, P., Russ. J. Gen. Chem., 2016, vol. 86, p. 1154. https://doi.org/10.1134/S1070363216050297

    Article  CAS  Google Scholar 

  17. Angajala, K.K., Vianala, S., Macha, R., Raghavender, M., Thupurani, M.K., and Pathi, P., SpringerPlus, 2016, vol. 5, no. 1, p. 423. https://doi.org/10.1186/s40064-016-2052-5

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  18. Raghavender, M., Kumar, A.K., Sunitha, V., Vishnu, T., and Jalapathi, P., Russ. J. Gen. Chem., 2020, vol. 90, p. 697. https://doi.org/10.1134/S1070363220040210

    Article  CAS  Google Scholar 

  19. Kim, D.-K., Kim, J., and Park, H.-J., Bioorg. Med. Chem. Lett., 2004, vol. 14, no. 10, p. 2401. https://doi.org/10.1016/j.bmcl.2004.03.024

    Article  CAS  PubMed  Google Scholar 

  20. Singh, B.K., Yadav, A.K., Kumar, B., Gaikwad, A., Sinha, S.K., Chaturvedi, V., and Tripathi, R.P., Carbohydr. Res., 2008, vol. 343, no. 7, p. 1153. https://doi.org/10.1016/j.carres.2008.02.013

    Article  CAS  PubMed  Google Scholar 

  21. Sunitha, V., Kumar, A.K., Jalapathi, P., and Lincoln, C., Russ. J. Gen. Chem., 2020, vol. 90, p. 154. https://doi.org/10.1134/S1070363220010247

    Article  CAS  Google Scholar 

  22. Bauer, A., Am. J. Clin. Pathol., 1966, vol. 45, p. 149. https://doi.org/10.1093/ajcp/45.4_ts.493

    Article  Google Scholar 

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ACKNOWLEDGMENTS

A. Kishore Kumar is grateful to IQAC and Principal Vardhaman College of Engineering, Hyderabad, Telangana, India for support and CFRD, Osmania University, Hyderabad, India for providing analytical support. V. Sunitha thanks the Head of the Department, and Principal, UCSS, Osmania University, Hyderabad and Secretary, TSWREIS for support.

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Authors and Affiliations

  1. Department of Humanities and Sciences, Vardhaman College of Engineering, Shamshabad, Hyderabad, 501218, Telangana, India

    A. Kishore Kumar, G. Ramesh & K. Jeshma

  2. elangana Social Welfare Residential Degree College for Women, Siddipet, Siddipet District, 506223, Telangana, India

    V. Sunitha

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  1. A. Kishore Kumar
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  2. V. Sunitha
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  3. G. Ramesh
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Correspondence to A. Kishore Kumar.

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Kumar, A.K., Sunitha, V., Ramesh, G. et al. Development of New Molecular Entities as Potent Antifungal Agents: Synthesis of Substituted 1,2,3-Triazoles. Russ J Gen Chem 91, 2546–2553 (2021). https://doi.org/10.1134/S1070363221120264

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