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Synthesis of 5-Aryl-4-aroyl-3-hydroxy-1-carboxymethyl-3-pyrroline-2-ones

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Abstract

The reaction of methyl aroylpyruvate with a mixture of aromatic aldehyde and glycocol in a dioxane–water mixture (1 : 1) leads to the formation of a new series of 5-aryl-4-aroyl-3-hydroxy-1-carboxymethyl-3-pyrroline-2-ones. Structure of the obtained compounds was determined by IR and 1H NMR spectroscopy methods.

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Authors and Affiliations

  1. Perm Pharmaceutical Academy, 614990, Perm, Russia

    V. L. Gein & E. V. Pastukhova

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  1. V. L. Gein
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  2. E. V. Pastukhova
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Correspondence to V. L. Gein.

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Additional information

Translated from Zhurnal Obshchei Khimii, 2021, Vol. 91, No. 7, pp. 987–991 https://doi.org/10.31857/S0044460X21070015.

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Gein, V.L., Pastukhova, E.V. Synthesis of 5-Aryl-4-aroyl-3-hydroxy-1-carboxymethyl-3-pyrroline-2-ones. Russ J Gen Chem 91, 1261–1264 (2021). https://doi.org/10.1134/S107036322107001X

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  • DOI: https://doi.org/10.1134/S107036322107001X

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