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Synthesis and Evaluation of Antibacterial Activity of 1,2,4-Oxadiazole-Containing Biphenylcarboxylic Acids

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Abstract

A one-pot method for the synthesis of biphenylcarboxylic acids containing 1,2,4-oxadiazole ring in the NaOH–DMSO system was developed. The results of in vitro experiments showed that the synthesized compounds exhibit antibacterial activity against susceptible strains of E. coli and S. aureus.

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Funding

This work was financially supported by the Russian Foundation for Basic Research (project no. 19-33-60064) using the equipment of the Resource Centers “Chemical Analysis and Materials Research Center” and “Magnetic Resonance Research Center” of the Research Park of St. Petersburg State University.

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Authors and Affiliations

  1. M.V. Dorogov Center for Transfer of Pharmaceutical Technologies, K.D. Ushinsky Yaroslavl State Pedagogical University, 150000, Yaroslavl, Russia

    M. V. Tarasenko, S. I. Presnukhina & A. A. Shetnev

  2. St. Petersburg State University, 199034, St. Petersburg, Russia

    S. V. Baikov

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  1. M. V. Tarasenko
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  2. S. I. Presnukhina
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  3. S. V. Baikov
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  4. A. A. Shetnev
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Correspondence to M. V. Tarasenko.

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Tarasenko, M.V., Presnukhina, S.I., Baikov, S.V. et al. Synthesis and Evaluation of Antibacterial Activity of 1,2,4-Oxadiazole-Containing Biphenylcarboxylic Acids. Russ J Gen Chem 90, 1611–1619 (2020). https://doi.org/10.1134/S1070363220090042

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