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Microwave Assisted Synthesis and Antimicrobial Activity of Novel Pyrrolidine Derivatives

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Abstract

Microwave assisted synthesis of 1-acetyl-2-benzylpyrrolidine-2-carboxylic acid and its derivatives has been developed with highly encouraging yields. 2-Benzyl-tert-butylpyrrolidine-1,2-dicarboxylate is used as an initial compound in the four steps synthesis of the target compounds. Structures of the products 5a–5h have been confirmed by spectroscopic methods. According to antimicrobial tests 1-acetyl-2-benzylpyrrolidine-2-carboxamide 5c is determined to be the most potent product.

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Acknowledgments

We thank the Department of Science and Technology. India under DST-FIST Program 2013 with grant no. SR/FST/CSI-252/2013. The authors are thankful to the GITAM for providing the necessary facility to do this work.

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Authors and Affiliations

  1. Department of Chemistry, GIS, GITAM, Rushikonda, Visakhapatnam, 530045, India

    K. Sreekanth & Anjali Jha

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  1. K. Sreekanth
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  2. Anjali Jha
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Correspondence to Anjali Jha.

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No conflict of interest was declared by the authors.

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Sreekanth, K., Jha, A. Microwave Assisted Synthesis and Antimicrobial Activity of Novel Pyrrolidine Derivatives. Russ J Gen Chem 90, 129–134 (2020). https://doi.org/10.1134/S107036322001020X

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  • DOI: https://doi.org/10.1134/S107036322001020X

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