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Synthesis and Anticancer Activity of Oxadiazole Incorporated Ellipticine Derivatives

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Abstract

A series of ellipticine derivatives 8a–8j containing oxadiazole structural block are synthesized and evaluated for their anticancer activity on human cancer cell lines (Colo-205, MCF-7, A-549, and KB). Among those, the products 8b, 8c, 8d, 8i exhibit potent cytotoxic activity with GI50 values ranging from <0.1 to 23.6 µM. The positive control etoposide GI50 values are ranging from 0.13 to 3.08 µM.

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Authors and Affiliations

  1. Department of Chemistry, Jawaharlal Nehru Technological University, Hyderabad, Telangana State, 500072, India

    S. Sumalatha

  2. Green Evolution Laboratories, Wangapally Village, Nalgonda, Telangana State, 508286, India

    S. Sumalatha

  3. Department of Chemistry, Satavahana University, Karimnagar, Telangana State, 505002, India

    V. Namrata

  4. Department of Life Sciences, Kakatiya University, Warangal, Telangana State, 506009, India

    M. Lakshmi

  5. Organic and Biomolecular Chemistry Division, CSIR Indian Institute of Chemical Technology, Hyderabad, 500107, India

    G. Sridhar

Authors
  1. S. Sumalatha
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  2. V. Namrata
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  3. M. Lakshmi
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  4. G. Sridhar
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Correspondence to G. Sridhar.

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Sumalatha, S., Namrata, V., Lakshmi, M. et al. Synthesis and Anticancer Activity of Oxadiazole Incorporated Ellipticine Derivatives. Russ J Gen Chem 89, 505–510 (2019). https://doi.org/10.1134/S107036321903023X

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  • DOI: https://doi.org/10.1134/S107036321903023X

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