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Synthesis of New Thiazolo[3,2-b][1,2,4]triazole Derivatives and Preliminary Evaluation of Their Biological Activity

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Abstract

Heterocyclization of 3-[(1H-1,2,4-triazol-3-yl)thio]pentane-2,4-dione afforded 1-(6-methylthiazolo[3,2-b][1,2,4]-triazol-5-yl)ethan-1-one, the reactions of which with hydroxylamine, hydrazincarboxamide, hydrazincarbothioamide, hydrazine hydrate and para-toluenesulfonyl hydrazide resulted in the formation of the corresponding derivatives. 1-(6-Methylthiazolo[3,2-b][1,2,4]triazol-5-yl)ethan-1-one oxime reacted with alkyl halides and phenyl isocyanate to produce the corresponding O-alkyl- and O-phenylcarbamoyl derivatives. The growth regulating activity of the compounds obtained was studied.

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Authors and Affiliations

  1. Russian-Armenian University, ul. H. Emina 123, Yerevan, 0051, Armenia

    A. P. Yengoyan

  2. Pesticide Synthesis and Plant Protection Laboratory, National Agrarian University of Armenia, Yerevan, Armenia

    A. P. Yengoyan, V. A. Pivazyan, E. A. Chazaryan & R. S. Hakobyan

Authors
  1. A. P. Yengoyan
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  2. V. A. Pivazyan
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  3. E. A. Chazaryan
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  4. R. S. Hakobyan
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Correspondence to A. P. Yengoyan.

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Russian Text © A.P. Yengoyan, V.A. Pivazyan, E.A. Ghazaryan, R.S. Hakobyan, 2019, published in Zhurnal Obshchei Khimii, 2019, Vol. 89, No. 1, pp. 39–44.

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Yengoyan, A.P., Pivazyan, V.A., Chazaryan, E.A. et al. Synthesis of New Thiazolo[3,2-b][1,2,4]triazole Derivatives and Preliminary Evaluation of Their Biological Activity. Russ J Gen Chem 89, 32–36 (2019). https://doi.org/10.1134/S1070363219010067

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  • DOI: https://doi.org/10.1134/S1070363219010067

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